TY - JOUR
T1 - The association of tumor location with recurrence free survival in non-muscle invasive bladder cancer
AU - Jansen, Ilaria
AU - Marquering, H
AU - de Bruin, Daniel M.
AU - Oddens, Jorg R.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Introduction&Objectives:Theinfluenceofintravesicaltumorlocationondiseaseoutcomeisrarelystudiedinpatientswithnon-muscleinvasivebladdercancer(NMIBC).Ouraimwastodeterminetheassociationoftumorlocationonrecurrence-freesurvival(RFS)inpatientswithprimary,solitary NMIBC.Materials&Methods:AfterIRBapproval,dataof840patientswhounderwenttransurethralresectionofbladdertumor(TURBT)in1hospitalbetween2000-2018wasretrospectivelycollected.Patientswithaprimary,solitaryNMIBCwereincluded.Caseswithirradicalresection,CISorconcomitantuppertracttumorwereexcluded.Tumorlocationwasassessedbycheckingtheoperation,cystoscopyandpathologyreport.AreasoftumorlocationwerebasedontheEAUbladdermap.Incaseofoverlappingareas,theareaoftumororiginwasselected.Moreover,patientsweredichotomizedintodorsalvs.non-dorsaltumors.Thedorsalareawasdefinedasthediamondborderedbybladderneck,trigone,posteriorwallandorifices.Thenon-dorsalareasarethelateralwalls,domeandanteriorwall.TheassociationoftumorlocationwithRFSwasassessedusingCoxregression. Median RFS was estimated using the Kaplan-Meier method. Statistical significance was considered at p<0.05.Results:Atotalof184patientswereincludedintotheanalysis.Themostcommontumorlocationwerethelateralwalls(45%,n=88).Altogether,25(14%)and69(38%)patientshadarecurrenceat1yrand5yrs,respectively.MedianRFSwas103months(mo).TumorslocatedattheanteriorwallwereassociatedwiththelowestRFS(median74mo)andattheposteriorwallwithhighestRFS(median133mo).NoassociationwasseenbetweentumorlocationandRFS,usingtheposteriorwallasareferencelocation(p=0.40).Dichotomizationshowedthat54%hadatumorinthedorsalareaofwhich9%hadarecurrencewithin1yr,comparedto19%inthenon-dorsalarea.MedianRFSinthedorsalareawas133moand48mointhenon-dorsalarea(Figure1;log-rankp=0.021).CoxanalysisshowedbetterRFSforpatientswithatumorinthedorsalarea(HR0.56,95%CI 0.36-0.88, p=0.01).Abstracts EAU20 Virtual Congress and Theme WeekEur Urol Open Sci 2020;19(Suppl 2):e1017
AB - Introduction&Objectives:Theinfluenceofintravesicaltumorlocationondiseaseoutcomeisrarelystudiedinpatientswithnon-muscleinvasivebladdercancer(NMIBC).Ouraimwastodeterminetheassociationoftumorlocationonrecurrence-freesurvival(RFS)inpatientswithprimary,solitary NMIBC.Materials&Methods:AfterIRBapproval,dataof840patientswhounderwenttransurethralresectionofbladdertumor(TURBT)in1hospitalbetween2000-2018wasretrospectivelycollected.Patientswithaprimary,solitaryNMIBCwereincluded.Caseswithirradicalresection,CISorconcomitantuppertracttumorwereexcluded.Tumorlocationwasassessedbycheckingtheoperation,cystoscopyandpathologyreport.AreasoftumorlocationwerebasedontheEAUbladdermap.Incaseofoverlappingareas,theareaoftumororiginwasselected.Moreover,patientsweredichotomizedintodorsalvs.non-dorsaltumors.Thedorsalareawasdefinedasthediamondborderedbybladderneck,trigone,posteriorwallandorifices.Thenon-dorsalareasarethelateralwalls,domeandanteriorwall.TheassociationoftumorlocationwithRFSwasassessedusingCoxregression. Median RFS was estimated using the Kaplan-Meier method. Statistical significance was considered at p<0.05.Results:Atotalof184patientswereincludedintotheanalysis.Themostcommontumorlocationwerethelateralwalls(45%,n=88).Altogether,25(14%)and69(38%)patientshadarecurrenceat1yrand5yrs,respectively.MedianRFSwas103months(mo).TumorslocatedattheanteriorwallwereassociatedwiththelowestRFS(median74mo)andattheposteriorwallwithhighestRFS(median133mo).NoassociationwasseenbetweentumorlocationandRFS,usingtheposteriorwallasareferencelocation(p=0.40).Dichotomizationshowedthat54%hadatumorinthedorsalareaofwhich9%hadarecurrencewithin1yr,comparedto19%inthenon-dorsalarea.MedianRFSinthedorsalareawas133moand48mointhenon-dorsalarea(Figure1;log-rankp=0.021).CoxanalysisshowedbetterRFSforpatientswithatumorinthedorsalarea(HR0.56,95%CI 0.36-0.88, p=0.01).Abstracts EAU20 Virtual Congress and Theme WeekEur Urol Open Sci 2020;19(Suppl 2):e1017
U2 - https://doi.org/10.1016/S2666-1683(20)33264-X
DO - https://doi.org/10.1016/S2666-1683(20)33264-X
M3 - Meeting Abstract
SN - 2666-1691
VL - 19
SP - 1017
EP - 1018
JO - European urology open science
JF - European urology open science
IS - 2
M1 - 663
ER -