The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells

P.S. Pinheiro, A.M. Jansen, H. de Wit, B. Tawfik, K.L. Madsen, M. Verhage, U. Gether, J.B. Sørensen

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25 Citations (Scopus)

Abstract

Protein Interacting with C Kinase 1 (PICK1) is a Bin/Amphiphysin/Rvs (BAR) domain protein involved in AMPA receptor trafficking. Here, we identify a selective role for PICK1 in the biogenesis of large, dense core vesicles (LDCVs) in mouse chromaffin cells. PICK1 colocalized with syntaxin-6, a marker for immature granules. In chromaffin cells isolated from a PICK1 knockout (KO) mouse the amount of exocytosis was reduced, while release kinetics and Ca
Original languageEnglish
Pages (from-to)10688-10700
JournalJournal of neuroscience
Volume34
Issue number32
DOIs
Publication statusPublished - 2014

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