TY - JOUR
T1 - The bvFTD phenocopy syndrome: a case study supported by repeated MRI, [18F]FDG-PET and pathological assessment
AU - van Engelen, Marie-Paule E.
AU - Rozemuller, Annemieke J. M.
AU - Ulugut Erkoyun, H. lya
AU - Groot, Colin
AU - Fieldhouse, Jay L. P.
AU - Koene, Ted
AU - Ossenkoppele, Rik
AU - Gossink, Flora T.
AU - Krudop, Welmoed A.
AU - Vijverberg, Everard G. B.
AU - Dols, Annemieke
AU - Barkhof, Frederik
AU - Berckel, Bart N. M. Van
AU - Scheltens, Philip
AU - Brain Bank, Netherlands
AU - Pijnenburg, Yolande A. L.
N1 - Funding Information: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Research of Alzheimer Center Amsterdam is part of the neurodegeneration research program of Amsterdam Neuroscience. Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting VUmc fonds. F.B. is supported by the National Institute for Health Research Biomedical Research Center at University College London Hospitals. Publisher Copyright: © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021
Y1 - 2021
N2 - A clinical syndrome with neuropsychiatric features of bvFTD without neuroimaging abnormalities and a lack of decline is a phenocopy of bvFTD (phFTD). Growing evidence suggests that psychological, psychiatric and environmental factors underlie phFTD. We describe a patient diagnosed with bvFTD prior to the revision of the diagnostic guidelines of FTD. Repeated neuroimaging was normal and there was no FTD pathology at autopsy, rejecting the diagnosis. We hypothesize on etiological factors that on hindsight might have played a role. This case report contributes to the understanding of phFTD and adds to the sparse literature of the postmortem assessment of phFTD.
AB - A clinical syndrome with neuropsychiatric features of bvFTD without neuroimaging abnormalities and a lack of decline is a phenocopy of bvFTD (phFTD). Growing evidence suggests that psychological, psychiatric and environmental factors underlie phFTD. We describe a patient diagnosed with bvFTD prior to the revision of the diagnostic guidelines of FTD. Repeated neuroimaging was normal and there was no FTD pathology at autopsy, rejecting the diagnosis. We hypothesize on etiological factors that on hindsight might have played a role. This case report contributes to the understanding of phFTD and adds to the sparse literature of the postmortem assessment of phFTD.
KW - Behavioral variant frontotemporal dementia
KW - diagnostic distinction of bvFTD and primary psychiatric diseases
KW - misdiagnosis
KW - neuropsychiatry
KW - phenocopy syndrome
UR - http://www.scopus.com/inward/record.url?scp=85104788528&partnerID=8YFLogxK
U2 - https://doi.org/10.1080/13554794.2021.1905855
DO - https://doi.org/10.1080/13554794.2021.1905855
M3 - Article
C2 - 33881963
SN - 1355-4794
VL - 27
SP - 181
EP - 189
JO - Neurocase
JF - Neurocase
IS - 2
ER -