TY - JOUR
T1 - The CADM2 Gene and Behavior
T2 - A Phenome-Wide Scan in UK-Biobank
AU - Pasman, Joëlle A.
AU - Chen, Zeli
AU - Smit, Dirk J.A.
AU - Vink, Jacqueline M.
AU - Van Den Oever, Michel C.
AU - Pattij, Tommy
AU - De Vries, Taco J.
AU - Abdellaoui, Abdel
AU - Verweij, Karin J.H.
N1 - Funding Information: KJHV and AA are supported by the Foundation Volksbond Rotterdam. AA is supported by ZonMw Grant 849200011 from The Netherlands Organisation for Health Research and Development. This project was supported by a grant from Amsterdam Neuroscience (2019). We acknowledge SURFsara for the usage of the Cartesius cluster computer (supported by NWO, EINF-457). This project was conducted under UK-Biobank application 40310. Publisher Copyright: © 2022, The Author(s).
PY - 2022/9
Y1 - 2022/9
N2 - The cell adhesion molecule 2 (CADM2) gene has appeared among the top associations in a wide range of genome-wide association studies (GWASs). This study aims to: (1) examine how widespread the role of CADM2 is in behavioural traits, and (2) investigate trait-specific effects on CADM2 expression levels across tissues. We conducted a phenome-wide association study in UK Biobank (N = 12,211–453,349) on 242 psycho-behavioral traits, both at the SNP and the gene-level. For comparison, we repeated the analyses for other large (and high LD) genes. We found significant associations between CADM2 and 50 traits (including cognitive, risk taking, and dietary traits), many more than for the comparison genes. We show that many trait associations are reduced when taking geographical stratification into account. S-Predixcan revealed that CADM2 expression in brain tissues was significantly associated with many traits; highly significant effects were also observed for lung, mammary, and adipose tissues. In conclusion, this study shows that the role of CADM2 extends to a wide range of psycho-behavioral traits, suggesting these traits may share a common biological denominator.
AB - The cell adhesion molecule 2 (CADM2) gene has appeared among the top associations in a wide range of genome-wide association studies (GWASs). This study aims to: (1) examine how widespread the role of CADM2 is in behavioural traits, and (2) investigate trait-specific effects on CADM2 expression levels across tissues. We conducted a phenome-wide association study in UK Biobank (N = 12,211–453,349) on 242 psycho-behavioral traits, both at the SNP and the gene-level. For comparison, we repeated the analyses for other large (and high LD) genes. We found significant associations between CADM2 and 50 traits (including cognitive, risk taking, and dietary traits), many more than for the comparison genes. We show that many trait associations are reduced when taking geographical stratification into account. S-Predixcan revealed that CADM2 expression in brain tissues was significantly associated with many traits; highly significant effects were also observed for lung, mammary, and adipose tissues. In conclusion, this study shows that the role of CADM2 extends to a wide range of psycho-behavioral traits, suggesting these traits may share a common biological denominator.
KW - CADM2
KW - Candidate gene
KW - Gene-expression
KW - Phenome-wide association study
KW - Risk behavior
UR - http://www.scopus.com/inward/record.url?scp=85134514258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85134514258&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85134514258&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/35867259
U2 - https://doi.org/10.1007/s10519-022-10109-8
DO - https://doi.org/10.1007/s10519-022-10109-8
M3 - Article
C2 - 35867259
SN - 0001-8244
VL - 52
SP - 306
EP - 314
JO - Behavior genetics
JF - Behavior genetics
IS - 4-5
ER -