The clinical value of the patient-reported multiple sclerosis neuropsychological screening questionnaire

Ilse M Nauta, Lisanne J Balk, Judith M Sonder, Hanneke E Hulst, Bernard Mj Uitdehaag, Luciano Fasotti, Brigit A de Jong

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16 Citations (Scopus)


BACKGROUND: Cognitive problems are difficult to identify in patients with multiple sclerosis (MS).

OBJECTIVE: To investigate the clinical applicability of the patient-reported MS Neuropsychological Screening Questionnaire (MSNQ-P).

METHODS: Cut-off scores were determined to differentiate between cognitively impaired ( n = 90), mildly cognitively impaired ( n = 115), and cognitively preserved ( n = 147) MS patients using receiver operating characteristic analyses.

RESULTS: We could not define specific and sensitive cut-off scores. Higher scores (≥27) did indicate cognitive impairment. Among patients with a higher education, lower scores (<12) indicated intact cognition.

CONCLUSION: Certain scores can indicate intact or impaired cognitive function. Still, MSNQ-P scores should be interpreted with caution.

Original languageEnglish
Pages (from-to)1543-1546
Issue number11
Early online date1 May 2018
Publication statusPublished - 1 Oct 2019

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