The clinical value of the patient-reported multiple sclerosis neuropsychological screening questionnaire

Ilse M Nauta; Lisanne J Balk; Judith M Sonder; Hanneke E Hulst; Bernard Mj Uitdehaag; Luciano Fasotti; Brigit A de Jong

doi:https://doi.org/10.1177/1352458518777295

The clinical value of the patient-reported multiple sclerosis neuropsychological screening questionnaire

Ilse M Nauta, Lisanne J Balk, Judith M Sonder, Hanneke E Hulst, Bernard Mj Uitdehaag, Luciano Fasotti, Brigit A de Jong

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

Abstract

BACKGROUND: Cognitive problems are difficult to identify in patients with multiple sclerosis (MS).

OBJECTIVE: To investigate the clinical applicability of the patient-reported MS Neuropsychological Screening Questionnaire (MSNQ-P).

METHODS: Cut-off scores were determined to differentiate between cognitively impaired ( n = 90), mildly cognitively impaired ( n = 115), and cognitively preserved ( n = 147) MS patients using receiver operating characteristic analyses.

RESULTS: We could not define specific and sensitive cut-off scores. Higher scores (≥27) did indicate cognitive impairment. Among patients with a higher education, lower scores (<12) indicated intact cognition.

CONCLUSION: Certain scores can indicate intact or impaired cognitive function. Still, MSNQ-P scores should be interpreted with caution.

Original language	English
Pages (from-to)	1543-1546
Journal	MULTIPLE SCLEROSIS
Volume	25
Issue number	11
Early online date	1 May 2018
DOIs	https://doi.org/10.1177/1352458518777295
Publication status	Published - 1 Oct 2019

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https://doi.org/10.1177/1352458518777295

Cite this

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title = "The clinical value of the patient-reported multiple sclerosis neuropsychological screening questionnaire",

abstract = "BACKGROUND: Cognitive problems are difficult to identify in patients with multiple sclerosis (MS).OBJECTIVE: To investigate the clinical applicability of the patient-reported MS Neuropsychological Screening Questionnaire (MSNQ-P).METHODS: Cut-off scores were determined to differentiate between cognitively impaired ( n = 90), mildly cognitively impaired ( n = 115), and cognitively preserved ( n = 147) MS patients using receiver operating characteristic analyses.RESULTS: We could not define specific and sensitive cut-off scores. Higher scores (≥27) did indicate cognitive impairment. Among patients with a higher education, lower scores (<12) indicated intact cognition.CONCLUSION: Certain scores can indicate intact or impaired cognitive function. Still, MSNQ-P scores should be interpreted with caution.",

author = "Nauta, {Ilse M} and Balk, {Lisanne J} and Sonder, {Judith M} and Hulst, {Hanneke E} and Uitdehaag, {Bernard Mj} and Luciano Fasotti and {de Jong}, {Brigit A}",

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T1 - The clinical value of the patient-reported multiple sclerosis neuropsychological screening questionnaire

AU - Nauta, Ilse M

AU - Balk, Lisanne J

AU - Sonder, Judith M

AU - Hulst, Hanneke E

AU - Uitdehaag, Bernard Mj

AU - Fasotti, Luciano

AU - de Jong, Brigit A

PY - 2019/10/1

Y1 - 2019/10/1

N2 - BACKGROUND: Cognitive problems are difficult to identify in patients with multiple sclerosis (MS).OBJECTIVE: To investigate the clinical applicability of the patient-reported MS Neuropsychological Screening Questionnaire (MSNQ-P).METHODS: Cut-off scores were determined to differentiate between cognitively impaired ( n = 90), mildly cognitively impaired ( n = 115), and cognitively preserved ( n = 147) MS patients using receiver operating characteristic analyses.RESULTS: We could not define specific and sensitive cut-off scores. Higher scores (≥27) did indicate cognitive impairment. Among patients with a higher education, lower scores (<12) indicated intact cognition.CONCLUSION: Certain scores can indicate intact or impaired cognitive function. Still, MSNQ-P scores should be interpreted with caution.

AB - BACKGROUND: Cognitive problems are difficult to identify in patients with multiple sclerosis (MS).OBJECTIVE: To investigate the clinical applicability of the patient-reported MS Neuropsychological Screening Questionnaire (MSNQ-P).METHODS: Cut-off scores were determined to differentiate between cognitively impaired ( n = 90), mildly cognitively impaired ( n = 115), and cognitively preserved ( n = 147) MS patients using receiver operating characteristic analyses.RESULTS: We could not define specific and sensitive cut-off scores. Higher scores (≥27) did indicate cognitive impairment. Among patients with a higher education, lower scores (<12) indicated intact cognition.CONCLUSION: Certain scores can indicate intact or impaired cognitive function. Still, MSNQ-P scores should be interpreted with caution.

U2 - https://doi.org/10.1177/1352458518777295

DO - https://doi.org/10.1177/1352458518777295

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C2 - 29775164

SN - 1352-4585

VL - 25

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