The Coagulant Response in Sepsis

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Abstract

Sepsis is often associated with systemic intravascular activation of coagulation, potentially leading to widespread microvascular deposits of fibrin, and thereby contributing to multiple organ dysfunction. A complex interaction exists between activation of inflammatory systems and the initiating and regulating pathways of coagulation. A diagnosis of sepsis-associated disseminated intravascular coagulation can be made by a combination of routinely available laboratory tests, for which simple diagnostic algorithms have become available. Strategies to inhibit coagulation activation may theoretically be justified and are being evaluated in clinical studies
Original languageEnglish
Pages (from-to)627-+
JournalClinics in chest medicine
Volume29
Issue number4
DOIs
Publication statusPublished - 2008

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