The Complement Pathway Is Activated in People with Human Immunodeficiency Virus and Is Associated with Non-AIDS Comorbidities

Ivan Vujkovic-Cvijin, Ornella Sortino, Eveline Verheij, Ferdinand W. Wit, Neeltje A. Kootstra, Brian Sellers, Maarten Schim van der Loeff, Yasmine Belkaid, Peter Reiss, Irini Sereti

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6 Citations (Scopus)

Abstract

Unbiased plasma proteomics in a matched case-control study of treated people with human immunodeficiency virus (PWH) revealed the complement cascade as being among the top pathways enriched in PWH. Specific complement components, namely C5, associated significantly with non-AIDS comorbidity prevalence, and did so more strongly than previously established predictive biomarkers.
Original languageEnglish
Pages (from-to)1405-1409
Number of pages5
JournalJournal of infectious diseases
Volume224
Issue number8
DOIs
Publication statusPublished - 15 Oct 2021

Keywords

  • HIV
  • biomarker
  • comorbidities
  • complement
  • noncommunicable diseases

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