The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency

S. Bulk, J. Berkhof, L. Rozendaal, N. C.Fransen Daalmeijer, M. Gök, F. A. De Schipper, F. J. Van Kemenade, P. J.F. Snijders, C. J.L.M. Meijer

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Abstract

In one geographical area, 14 high-risk human papillomavirus types in cervical intraepithelial neoplasia (CIN2/3; n=139) and cervical squamous cell carcinoma (SCC; n=84) were analysed. HPV18 was more prevalent in SCC than CIN2/3 (OR 9.8; 95% confidence interval: 2.5-39). Other high-risk types prevalences corresponded in CIN2/3 and SCC. Evaluations using CIN2/3 as a measure of efficiency underestimate the contribution of HPV18 to SCC.

Original languageEnglish
Pages (from-to)1234-1236
Number of pages3
JournalBritish journal of cancer
Volume96
Issue number8
DOIs
Publication statusPublished - 23 Apr 2007

Keywords

  • Cervical intraepithelial neoplasia
  • Epidemiology
  • Human papillomavirus
  • PALGA
  • Squamous cell carcinoma

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