The course of post-stroke apathy in relation to cognitive functioning: a prospective longitudinal cohort study

N A Lammers; L L Van Wanrooij; J W van Dalen; W A van Gool; B Schmand; E P Moll van Charante; E H F de Haan; D Van de Beek; P J Nederkoorn; E Richard

doi:https://doi.org/10.1080/13825585.2021.1967276

The course of post-stroke apathy in relation to cognitive functioning: a prospective longitudinal cohort study

N A Lammers, L L Van Wanrooij, J W van Dalen, W A van Gool, B Schmand, E P Moll van Charante, E H F de Haan, D Van de Beek, P J Nederkoorn, E Richard

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

Apathy is common after stroke and has been associated with cognitive impairment. However, causality between post-stroke apathy and cognitive impairment remains unclear. We assessed the course of apathy in relation to changes in cognitive functioning in stroke survivors. Using the Apathy Scale (AS) and cognitive tests on memory, processing speed and executive functioning at six- and 15 months post-stroke we tested for associations between (1) AS-scores and (change in) cognitive scores; (2) apathy course (persistent/incident/resolved) and cognitive change scores. Of 117 included participants, 29% had persistent apathy, 13% apathy resolving over time and 10% apathy emerging between 6-15 months post-stroke. Higher AS-scores were cross-sectionally and longitudinally associated with lower cognitive scores. Relations between apathy and cognitive change scores were ambiguous. These inconsistent relations between apathy and changes in cognition over time suggest that post-stroke apathy does not directly impact cognitive performance. Both these sequelae of stroke require separate attention.

Original language	English
Pages (from-to)	94-105
Number of pages	12
Journal	Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition
Volume	30
Issue number	1
Early online date	8 Sept 2021
DOIs	https://doi.org/10.1080/13825585.2021.1967276
Publication status	Published - 2023

Keywords

Stroke
apathy scale
cognition
cognitive impairment
cross-sectional
longitudinal
post-stroke apathy

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Lammers, N. A., Van Wanrooij, L. L., van Dalen, J. W., van Gool, W. A., Schmand, B., Moll van Charante, E. P., de Haan, E. H. F., Van de Beek, D., Nederkoorn, P. J., & Richard, E. (2023). The course of post-stroke apathy in relation to cognitive functioning: a prospective longitudinal cohort study. Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, 30(1), 94-105. https://doi.org/10.1080/13825585.2021.1967276

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title = "The course of post-stroke apathy in relation to cognitive functioning: a prospective longitudinal cohort study",

abstract = "Apathy is common after stroke and has been associated with cognitive impairment. However, causality between post-stroke apathy and cognitive impairment remains unclear. We assessed the course of apathy in relation to changes in cognitive functioning in stroke survivors. Using the Apathy Scale (AS) and cognitive tests on memory, processing speed and executive functioning at six- and 15 months post-stroke we tested for associations between (1) AS-scores and (change in) cognitive scores; (2) apathy course (persistent/incident/resolved) and cognitive change scores. Of 117 included participants, 29% had persistent apathy, 13% apathy resolving over time and 10% apathy emerging between 6-15 months post-stroke. Higher AS-scores were cross-sectionally and longitudinally associated with lower cognitive scores. Relations between apathy and cognitive change scores were ambiguous. These inconsistent relations between apathy and changes in cognition over time suggest that post-stroke apathy does not directly impact cognitive performance. Both these sequelae of stroke require separate attention.",

keywords = "Stroke, apathy scale, cognition, cognitive impairment, cross-sectional, longitudinal, post-stroke apathy",

author = "Lammers, {N A} and {Van Wanrooij}, {L L} and {van Dalen}, {J W} and {van Gool}, {W A} and B Schmand and {Moll van Charante}, {E P} and {de Haan}, {E H F} and {Van de Beek}, D and Nederkoorn, {P J} and E Richard",

note = "Funding Information: This work was supported by The Netherlands Organization for Health Research and Development [grant number 171002302, grant no 016116358]; The Netherlands Heart Foundation [grant number 2009B095]; European Research Council (ERC) Starting Grant [grant number 281156]; and European Research Council (ERC) Advanced Grant [grant number 339374]. There are no disclosures to report. Publisher Copyright: {\textcopyright} 2021 Informa UK Limited, trading as Taylor & Francis Group.",

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language = "English",

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Lammers, NA, Van Wanrooij, LL, van Dalen, JW, van Gool, WA, Schmand, B, Moll van Charante, EP, de Haan, EHF, Van de Beek, D , Nederkoorn, PJ & Richard, E 2023, 'The course of post-stroke apathy in relation to cognitive functioning: a prospective longitudinal cohort study', Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, vol. 30, no. 1, pp. 94-105. https://doi.org/10.1080/13825585.2021.1967276

The course of post-stroke apathy in relation to cognitive functioning: a prospective longitudinal cohort study. / Lammers, N A; Van Wanrooij, L L; van Dalen, J W et al.
In: Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, Vol. 30, No. 1, 2023, p. 94-105.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - The course of post-stroke apathy in relation to cognitive functioning

T2 - a prospective longitudinal cohort study

AU - Lammers, N A

AU - Van Wanrooij, L L

AU - van Dalen, J W

AU - van Gool, W A

AU - Schmand, B

AU - Moll van Charante, E P

AU - de Haan, E H F

AU - Van de Beek, D

AU - Nederkoorn, P J

AU - Richard, E

N1 - Funding Information: This work was supported by The Netherlands Organization for Health Research and Development [grant number 171002302, grant no 016116358]; The Netherlands Heart Foundation [grant number 2009B095]; European Research Council (ERC) Starting Grant [grant number 281156]; and European Research Council (ERC) Advanced Grant [grant number 339374]. There are no disclosures to report. Publisher Copyright: © 2021 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2023

Y1 - 2023

N2 - Apathy is common after stroke and has been associated with cognitive impairment. However, causality between post-stroke apathy and cognitive impairment remains unclear. We assessed the course of apathy in relation to changes in cognitive functioning in stroke survivors. Using the Apathy Scale (AS) and cognitive tests on memory, processing speed and executive functioning at six- and 15 months post-stroke we tested for associations between (1) AS-scores and (change in) cognitive scores; (2) apathy course (persistent/incident/resolved) and cognitive change scores. Of 117 included participants, 29% had persistent apathy, 13% apathy resolving over time and 10% apathy emerging between 6-15 months post-stroke. Higher AS-scores were cross-sectionally and longitudinally associated with lower cognitive scores. Relations between apathy and cognitive change scores were ambiguous. These inconsistent relations between apathy and changes in cognition over time suggest that post-stroke apathy does not directly impact cognitive performance. Both these sequelae of stroke require separate attention.

AB - Apathy is common after stroke and has been associated with cognitive impairment. However, causality between post-stroke apathy and cognitive impairment remains unclear. We assessed the course of apathy in relation to changes in cognitive functioning in stroke survivors. Using the Apathy Scale (AS) and cognitive tests on memory, processing speed and executive functioning at six- and 15 months post-stroke we tested for associations between (1) AS-scores and (change in) cognitive scores; (2) apathy course (persistent/incident/resolved) and cognitive change scores. Of 117 included participants, 29% had persistent apathy, 13% apathy resolving over time and 10% apathy emerging between 6-15 months post-stroke. Higher AS-scores were cross-sectionally and longitudinally associated with lower cognitive scores. Relations between apathy and cognitive change scores were ambiguous. These inconsistent relations between apathy and changes in cognition over time suggest that post-stroke apathy does not directly impact cognitive performance. Both these sequelae of stroke require separate attention.

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KW - apathy scale

KW - cognition

KW - cognitive impairment

KW - cross-sectional

KW - longitudinal

KW - post-stroke apathy

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U2 - https://doi.org/10.1080/13825585.2021.1967276

DO - https://doi.org/10.1080/13825585.2021.1967276

M3 - Article

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JO - Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition

JF - Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition

IS - 1

ER -

Lammers NA, Van Wanrooij LL, van Dalen JW, van Gool WA, Schmand B, Moll van Charante EP et al. The course of post-stroke apathy in relation to cognitive functioning: a prospective longitudinal cohort study. Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition. 2023;30(1):94-105. Epub 2021 Sept 8. doi: https://doi.org/10.1080/13825585.2021.1967276

The course of post-stroke apathy in relation to cognitive functioning: a prospective longitudinal cohort study

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Keywords

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