TY - JOUR
T1 - The effect of age on ventilation management and clinical outcomes in critically ill COVID-19 patients--insights from the PRoVENT-COVID study
AU - Hol, Liselotte
AU - van Oosten, Paula
AU - Nijbroek, Sunny
AU - Tsonas, Anissa
AU - Botta, Michela
AU - Neto, Ary Serpa
AU - Paulus, Frederique
AU - PRoVENT–COVID
AU - Collaborative group
AU - Schultz, Marcus
N1 - Funding Information: PRoVENT–COVID was funded by Amsterdam UMC, location AMC, Amsterdam, The Netherlands. Publisher Copyright: © 2022 Hol et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2022/1/31
Y1 - 2022/1/31
N2 - INTRODUCTION: We analyzed the association of age with ventilation practice and outcomes in critically ill COVID-19 patients requiring invasive ventilation. METHODS: Posthoc analysis of the PRoVENT-COVID study, an observational study performed in 22 ICUs in the first 3 months of the national outbreak in the Netherlands. The coprimary endpoint was a set of ventilator parameters, including tidal volume normalized for predicted bodyweight, positive end-expiratory pressure, driving pressure, and respiratory system compliance in the first 4 days of invasive ventilation. Secondary endpoints were other ventilation parameters, the use of rescue therapies, pulmonary and extrapulmonary complications in the first 28 days in the ICU, hospital- and ICU stay, and mortality. RESULTS: 1122 patients were divided into four groups based on age quartiles. No meaningful differences were found in ventilation parameters and in the use of rescue therapies for refractory hypoxemia in the first 4 days of invasive ventilation. Older patients received more often a tracheostomy, developed more frequently acute kidney injury and myocardial infarction, stayed longer in hospital and ICU, and had a higher mortality. CONCLUSIONS: In this cohort of invasively ventilated critically ill COVID-19 patients, age had no effect on ventilator management. Higher age was associated with more complications, longer length of stay in ICU and hospital and a higher mortality.
AB - INTRODUCTION: We analyzed the association of age with ventilation practice and outcomes in critically ill COVID-19 patients requiring invasive ventilation. METHODS: Posthoc analysis of the PRoVENT-COVID study, an observational study performed in 22 ICUs in the first 3 months of the national outbreak in the Netherlands. The coprimary endpoint was a set of ventilator parameters, including tidal volume normalized for predicted bodyweight, positive end-expiratory pressure, driving pressure, and respiratory system compliance in the first 4 days of invasive ventilation. Secondary endpoints were other ventilation parameters, the use of rescue therapies, pulmonary and extrapulmonary complications in the first 28 days in the ICU, hospital- and ICU stay, and mortality. RESULTS: 1122 patients were divided into four groups based on age quartiles. No meaningful differences were found in ventilation parameters and in the use of rescue therapies for refractory hypoxemia in the first 4 days of invasive ventilation. Older patients received more often a tracheostomy, developed more frequently acute kidney injury and myocardial infarction, stayed longer in hospital and ICU, and had a higher mortality. CONCLUSIONS: In this cohort of invasively ventilated critically ill COVID-19 patients, age had no effect on ventilator management. Higher age was associated with more complications, longer length of stay in ICU and hospital and a higher mortality.
KW - Age
KW - Coronavirus disease 2019
KW - Covid-19
KW - Critical care
KW - Invasive ventilation
KW - Mortality
UR - http://www.scopus.com/inward/record.url?scp=85125001311&partnerID=8YFLogxK
U2 - https://doi.org/10.18632/aging.203863
DO - https://doi.org/10.18632/aging.203863
M3 - Article
C2 - 35100136
SN - 1945-4589
VL - 14
SP - 1087
EP - 1099
JO - Aging
JF - Aging
IS - 3
ER -