The effect of APOE genotype on clinical phenotype in Alzheimer disease

W. M. Van Der Flier, S. N.M. Schoonenboom, Y. A.L. Pijnenburg, N. C. Fox, P. Scheltens

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71 Citations (Scopus)


The authors classified 100 patients with Alzheimer disease (AD) as presenting with a memory or nonmemory phenotype. APOE genotype was determined. There was an association between APOE-ε4 and clinical phenotype (odds ratio = 3.0; 95% CI: 1.2 to 7.8), suggesting that two subtypes of AD can be identified. The typical amnestic phenotype seems to be promoted by the APOE-ε4 allele, whereas the atypical nonmemory phenotype occurs in the absence of the APOE-ε4 allele.

Original languageEnglish
Pages (from-to)526-527
Number of pages2
Issue number3
Publication statusPublished - 1 Aug 2006

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