TY - JOUR
T1 - The Effect of Myopenia on the Inflammatory Response Early after Colorectal Surgery
AU - Smeets, Boudewijn J. J.
AU - Brinkman, David J.
AU - Horsten, Eelco C. J.
AU - Langius, Jacqueline A. E.
AU - Rutten, Harm J. T.
AU - de Jonge, Wouter J.
AU - Luyer, Misha D. P.
PY - 2018
Y1 - 2018
N2 - Background: Myopenia (low skeletal muscle mass) is associated with an increased risk of complications following colorectal surgery, however, the underlying mechanism is poorly understood. This study investigates the effect of myopenia on the early postoperative systemic inflammatory response. Materials and methods: In 78 patients undergoing colorectal surgery, the presence of myopenia was preoperatively assessed using computed tomography images of the third lumbar vertebra. Interleukin-8 (IL-8) and soluble tumor necrosis factor receptor-1 (TNFRSF1A) were measured in plasma before and 4 h after start of surgery as part of a randomized controlled trial investigating the effect of perioperative gum chewing on the inflammatory response. Multivariable linear regression analysis was performed to assess the effect of myopenia on inflammatory markers while correcting for possible confounders. Results: Four hours after start of surgery, IL-8 was higher in patients with myopenia than in patients without myopenia (352 ± 268 vs. 239 ± 211 pg/ml, P = 0.048), while TNFRSF1A was similar between groups. After adjusting for sex and the intervention with perioperative gum chewing, myopenia remained associated with higher postoperative IL-8 concentrations (P = 0.047). Conclusion: Myopenia may affect IL-8 early after colorectal surgery. However, more studies are needed to validate these findings.
AB - Background: Myopenia (low skeletal muscle mass) is associated with an increased risk of complications following colorectal surgery, however, the underlying mechanism is poorly understood. This study investigates the effect of myopenia on the early postoperative systemic inflammatory response. Materials and methods: In 78 patients undergoing colorectal surgery, the presence of myopenia was preoperatively assessed using computed tomography images of the third lumbar vertebra. Interleukin-8 (IL-8) and soluble tumor necrosis factor receptor-1 (TNFRSF1A) were measured in plasma before and 4 h after start of surgery as part of a randomized controlled trial investigating the effect of perioperative gum chewing on the inflammatory response. Multivariable linear regression analysis was performed to assess the effect of myopenia on inflammatory markers while correcting for possible confounders. Results: Four hours after start of surgery, IL-8 was higher in patients with myopenia than in patients without myopenia (352 ± 268 vs. 239 ± 211 pg/ml, P = 0.048), while TNFRSF1A was similar between groups. After adjusting for sex and the intervention with perioperative gum chewing, myopenia remained associated with higher postoperative IL-8 concentrations (P = 0.047). Conclusion: Myopenia may affect IL-8 early after colorectal surgery. However, more studies are needed to validate these findings.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044049035&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29537903
U2 - https://doi.org/10.1080/01635581.2018.1445763
DO - https://doi.org/10.1080/01635581.2018.1445763
M3 - Article
C2 - 29537903
SN - 0163-5581
VL - 70
SP - 460
EP - 466
JO - Nutrition and cancer
JF - Nutrition and cancer
IS - 3
ER -