TY - JOUR
T1 - The effect of non-invasive brain stimulation on executive functioning in healthy controls: A systematic review and meta-analysis
AU - de Boer, Nina S.
AU - Schluter, Renée S.
AU - Daams, Joost G.
AU - van der Werf, Ysbrand D.
AU - Goudriaan, Anna E.
AU - van Holst, Ruth J.
N1 - Funding Information: This research was funded by a VIDI (NWO-ZonMw) grant [grant number 91713354 ] to AEG. This funder had no influence on the paper. All authors critically reviewed the content and approved the final version for publication. Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - In recent years, there has been a heightened interest in the effect of non-invasive brain stimulation on executive functioning. However, there is no comprehensive overview of its effects on different executive functioning domains in healthy individuals. Here, we assessed the state of the field by conducting a systematic review and meta-analysis on the effectiveness of non-invasive brain stimulation (i.e. repetitive transcranial magnetic stimulation and transcranial direct current stimulation) over prefrontal regions on tasks assessing working memory, inhibition, flexibility, planning and initiation performance. Our search yielded 63 studies (n = 1537), and the effectiveness of excitatory and inhibitory non-invasive brain stimulation were assessed per executive functioning task. Our analyses showed that excitatory non-invasive brain stimulation had a small but positive effect on Stop Signal Task and Go/No-Go Task performance, and that inhibitory stimulation had a small negative effect on Flanker Task performance. Non-invasive brain stimulation did not affect performance on working memory and flexibility tasks, and effects on planning tasks were inconclusive.
AB - In recent years, there has been a heightened interest in the effect of non-invasive brain stimulation on executive functioning. However, there is no comprehensive overview of its effects on different executive functioning domains in healthy individuals. Here, we assessed the state of the field by conducting a systematic review and meta-analysis on the effectiveness of non-invasive brain stimulation (i.e. repetitive transcranial magnetic stimulation and transcranial direct current stimulation) over prefrontal regions on tasks assessing working memory, inhibition, flexibility, planning and initiation performance. Our search yielded 63 studies (n = 1537), and the effectiveness of excitatory and inhibitory non-invasive brain stimulation were assessed per executive functioning task. Our analyses showed that excitatory non-invasive brain stimulation had a small but positive effect on Stop Signal Task and Go/No-Go Task performance, and that inhibitory stimulation had a small negative effect on Flanker Task performance. Non-invasive brain stimulation did not affect performance on working memory and flexibility tasks, and effects on planning tasks were inconclusive.
KW - Executive functioning
KW - Flexibility
KW - Healthy individuals
KW - Inhibition
KW - Initiation
KW - Meta-analysis
KW - Non-invasive brain stimulation
KW - Planning
KW - Transcranial electrical current stimulation
KW - Transcranial magnetic stimulation
KW - Working memory
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85101646515&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/33503477
UR - http://www.scopus.com/inward/record.url?scp=85101646515&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neubiorev.2021.01.013
DO - https://doi.org/10.1016/j.neubiorev.2021.01.013
M3 - Review article
C2 - 33503477
SN - 0149-7634
VL - 125
SP - 122
EP - 147
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -