TY - JOUR
T1 - The effect of revascularization of a chronic total coronary occlusion on electrocardiographic variables. A sub-study of the EXPLORE trial
AU - van Dongen, Ivo M.
AU - Kolk, Maarten Z. H.
AU - Elias, Joëlle
AU - Meijborg, Veronique M. F.
AU - Coronel, Ruben
AU - de Bakker, Jacques M. T.
AU - Claessen, Bimmer E. P. M.
AU - Delewi, Ronak
AU - Ouweneel, Dagmar M.
AU - Scheunhage, Esther M.
AU - van der Schaaf, René J.
AU - Suttorp, Maarten-Jan
AU - Bax, Matthijs
AU - Marques, Koen M.
AU - Postema, Pieter G.
AU - Wilde, Arthur A. M.
AU - Henriques, José P. S.
PY - 2018
Y1 - 2018
N2 - Introduction: Chronic total coronary occlusions (CTOs) have been associated with a higher prevalence of ventricular arrhythmias compared to patients without a CTO. We evaluated the effect of CTO revascularization on electrocardiographic (ECG) variables. Methods: We studied a selection of ST-elevation myocardial infarction patients with a concomitant CTO enrolled in the EXPLORE trial. ECG variables and cardiac function were analysed at baseline and at 4 months follow-up. Results: Patients were randomized to percutaneous coronary intervention (PCI) of their CTO (n = 77) or to no-CTO PCI (n = 81). At follow-up, median QT dispersion was significantly lower in the CTO PCI group compared to the no-CTO PCI group (46 ms [33–58] vs. 54 ms [37–68], P = 0.043). No independent association was observed between ECG variables and cardiac function. Conclusion: Revascularization of a CTO after STEMI significantly shortened QT dispersion at 4 months follow-up. These findings support the hypothesis that CTO revascularization reduces the pro-arrhythmic substrate in CTO patients.
AB - Introduction: Chronic total coronary occlusions (CTOs) have been associated with a higher prevalence of ventricular arrhythmias compared to patients without a CTO. We evaluated the effect of CTO revascularization on electrocardiographic (ECG) variables. Methods: We studied a selection of ST-elevation myocardial infarction patients with a concomitant CTO enrolled in the EXPLORE trial. ECG variables and cardiac function were analysed at baseline and at 4 months follow-up. Results: Patients were randomized to percutaneous coronary intervention (PCI) of their CTO (n = 77) or to no-CTO PCI (n = 81). At follow-up, median QT dispersion was significantly lower in the CTO PCI group compared to the no-CTO PCI group (46 ms [33–58] vs. 54 ms [37–68], P = 0.043). No independent association was observed between ECG variables and cardiac function. Conclusion: Revascularization of a CTO after STEMI significantly shortened QT dispersion at 4 months follow-up. These findings support the hypothesis that CTO revascularization reduces the pro-arrhythmic substrate in CTO patients.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85050259915&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30177338
U2 - https://doi.org/10.1016/j.jelectrocard.2018.07.012
DO - https://doi.org/10.1016/j.jelectrocard.2018.07.012
M3 - Article
C2 - 30177338
SN - 0022-0736
VL - 51
SP - 906
EP - 912
JO - Journal of electrocardiology
JF - Journal of electrocardiology
IS - 5
ER -