The effect of the neuroblastoma-seeking agent meta-Iodobenzylguanidine (MIBG) on NADH-driven superoxide formation and NADH-driven lipid peroxidation in beef heart submitochondrial particles

J. Cornelissen; A.B.P. van Kuilenburg; P.A. Voûte; A.H. van Gennip

doi:https://doi.org/10.1016/S0959-8049(96)00488-1

The effect of the neuroblastoma-seeking agent meta-Iodobenzylguanidine (MIBG) on NADH-driven superoxide formation and NADH-driven lipid peroxidation in beef heart submitochondrial particles

J. Cornelissen, A.B.P. van Kuilenburg, P.A. Voûte, A.H. van Gennip

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Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

In this paper we report the effects of the neuroblastoma-seeking agent meta-iodobenzylguanidine (MIBG) on NADH-driven superoxide formation and NADH-driven lipid peroxidation in beef heart submitochondrial particles. MIBG is a structural analogue of noradrenaline and is capable of inhibiting complex I and complex III of the respiratory chain. The results of our studies show that MIBG enhanced both NADH-driven superoxide formation and NADH-driven lipid peroxidation at concentrations that are likely to exist inside mitochondria of the target cells of neuroblastoma patients treated with [131I]MIBG. The effect of MIBG is comparable to that of rotenone (an inhibitor of complex I) rather than that of antimycin (an inhibitor of complex III). These results suggest that the formation of superoxide and lipid peroxidation contributes to the cytotoxicity of [131I]MIBG

Original language	Undefined/Unknown
Pages (from-to)	421-424
Journal	European Journal of Cancer
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/S0959-8049(96)00488-1
Publication status	Published - 1997

Keywords

AMC wi-eigen

Access to Document

https://doi.org/10.1016/S0959-8049(96)00488-1

https://pure.uva.nl/ws/files/3045611/3264_30185y.pdf

Cite this

@article{55b12058e4af4fbd98a54ac74085244b,

title = "The effect of the neuroblastoma-seeking agent meta-Iodobenzylguanidine (MIBG) on NADH-driven superoxide formation and NADH-driven lipid peroxidation in beef heart submitochondrial particles",

abstract = "In this paper we report the effects of the neuroblastoma-seeking agent meta-iodobenzylguanidine (MIBG) on NADH-driven superoxide formation and NADH-driven lipid peroxidation in beef heart submitochondrial particles. MIBG is a structural analogue of noradrenaline and is capable of inhibiting complex I and complex III of the respiratory chain. The results of our studies show that MIBG enhanced both NADH-driven superoxide formation and NADH-driven lipid peroxidation at concentrations that are likely to exist inside mitochondria of the target cells of neuroblastoma patients treated with [131I]MIBG. The effect of MIBG is comparable to that of rotenone (an inhibitor of complex I) rather than that of antimycin (an inhibitor of complex III). These results suggest that the formation of superoxide and lipid peroxidation contributes to the cytotoxicity of [131I]MIBG",

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author = "J. Cornelissen and {van Kuilenburg}, A.B.P. and P.A. Vo{\^u}te and {van Gennip}, A.H.",

year = "1997",

doi = "https://doi.org/10.1016/S0959-8049(96)00488-1",

language = "Undefined/Unknown",

volume = "33",

pages = "421--424",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Limited",

number = "3",

}

The effect of the neuroblastoma-seeking agent meta-Iodobenzylguanidine (MIBG) on NADH-driven superoxide formation and NADH-driven lipid peroxidation in beef heart submitochondrial particles. / Cornelissen, J.; van Kuilenburg, A.B.P.; Voûte, P.A. et al.
In: European Journal of Cancer, Vol. 33, No. 3, 1997, p. 421-424.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The effect of the neuroblastoma-seeking agent meta-Iodobenzylguanidine (MIBG) on NADH-driven superoxide formation and NADH-driven lipid peroxidation in beef heart submitochondrial particles

AU - Cornelissen, J.

AU - van Kuilenburg, A.B.P.

AU - Voûte, P.A.

AU - van Gennip, A.H.

PY - 1997

Y1 - 1997

N2 - In this paper we report the effects of the neuroblastoma-seeking agent meta-iodobenzylguanidine (MIBG) on NADH-driven superoxide formation and NADH-driven lipid peroxidation in beef heart submitochondrial particles. MIBG is a structural analogue of noradrenaline and is capable of inhibiting complex I and complex III of the respiratory chain. The results of our studies show that MIBG enhanced both NADH-driven superoxide formation and NADH-driven lipid peroxidation at concentrations that are likely to exist inside mitochondria of the target cells of neuroblastoma patients treated with [131I]MIBG. The effect of MIBG is comparable to that of rotenone (an inhibitor of complex I) rather than that of antimycin (an inhibitor of complex III). These results suggest that the formation of superoxide and lipid peroxidation contributes to the cytotoxicity of [131I]MIBG

AB - In this paper we report the effects of the neuroblastoma-seeking agent meta-iodobenzylguanidine (MIBG) on NADH-driven superoxide formation and NADH-driven lipid peroxidation in beef heart submitochondrial particles. MIBG is a structural analogue of noradrenaline and is capable of inhibiting complex I and complex III of the respiratory chain. The results of our studies show that MIBG enhanced both NADH-driven superoxide formation and NADH-driven lipid peroxidation at concentrations that are likely to exist inside mitochondria of the target cells of neuroblastoma patients treated with [131I]MIBG. The effect of MIBG is comparable to that of rotenone (an inhibitor of complex I) rather than that of antimycin (an inhibitor of complex III). These results suggest that the formation of superoxide and lipid peroxidation contributes to the cytotoxicity of [131I]MIBG

KW - AMC wi-eigen

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DO - https://doi.org/10.1016/S0959-8049(96)00488-1

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SN - 0959-8049

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SP - 421

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JO - European Journal of Cancer

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