TY - JOUR
T1 - The effects of a preconception lifestyle intervention on childhood cardiometabolic health—follow-up of a randomized controlled trial
AU - Mintjens, Stijn
AU - van Poppel, Mireille N. M.
AU - Groen, Henk
AU - Hoek, Annemieke
AU - Mol, Ben Willem
AU - Painter, Rebecca C.
AU - Gemke, Reinoud J. B. J.
AU - Roseboom, Tessa J.
N1 - Funding Information: Conflicts of Interest: S.M., M.N.M.v.P., H.G., A.H., B.W.M., R.C.P., R.J.B.J.G. and T.J.R. declare no conflict of interest relevant to this study. Outside the work submitted, A.H. declares consultancy fees and grants by Ferring Pharmaceutical BV. B.W.M is supported by a NHMRC practitioner Fellowship and reports consultancy for ObsEva, Merck, Merck KGaA and Guerbet. R.P. reports board membership for the Dutch Gezondheidsraad NVVH guideline committee, and travel expenses reimbursement for ESHRE meeting Barcelona 2018 (June). Funding Information: Funding: This study was supported by a grant of the Dutch Heart Foundation (2013T085) and by a DynaHealth H2020 grant (agreement No 633595). The funders had no role in the design, conduct and interpretation of the study. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Maternal obesity is associated with adverse metabolic outcomes in her offspring, from the earliest stages of development leading to obesity and poorer cardiometabolic health in her offspring. We investigated whether an effective preconception lifestyle intervention in obese women affected cardiometabolic health of their offspring. We randomly allocated 577 infertile women with obesity to a 6-month lifestyle intervention, or to prompt infertility management. Of the 305 eligible children, despite intensive efforts, 17 in the intervention and 29 in the control group were available for follow-up at age 3–6 years. We compared the child’s Body Mass Index (BMI) Z score, waist and hip circumference, body-fat percentage, blood pressure Z scores, pulse wave velocity and serum lipids, glucose and insulin concentrations. Between the intervention and control groups, the mean (±SD) offspring BMI Z score (0.69 (±1.17) vs. 0.62 (±1.04)) and systolic and diastolic blood pressure Z scores (0.45 (±0.65) vs. 0.54 (±0.57); 0.91 (±0.66) vs. 0.96 (±0.57)) were similar, although elevated compared to the norm population. We also did not detect any differences between the groups in the other outcomes. In this study, we could not detect effects of a preconception lifestyle intervention in obese infertile women on the cardiometabolic health of their offspring. Low follow-up rates, perhaps due to the children’s age or the subject matter, combined with selection bias abating contrast in periconceptional weight between participating mothers, hampered the detection of potential effects. Future studies that account for these factors are needed to confirm whether a preconception lifestyle intervention may improve the cardiometabolic health of children of obese mothers.
AB - Maternal obesity is associated with adverse metabolic outcomes in her offspring, from the earliest stages of development leading to obesity and poorer cardiometabolic health in her offspring. We investigated whether an effective preconception lifestyle intervention in obese women affected cardiometabolic health of their offspring. We randomly allocated 577 infertile women with obesity to a 6-month lifestyle intervention, or to prompt infertility management. Of the 305 eligible children, despite intensive efforts, 17 in the intervention and 29 in the control group were available for follow-up at age 3–6 years. We compared the child’s Body Mass Index (BMI) Z score, waist and hip circumference, body-fat percentage, blood pressure Z scores, pulse wave velocity and serum lipids, glucose and insulin concentrations. Between the intervention and control groups, the mean (±SD) offspring BMI Z score (0.69 (±1.17) vs. 0.62 (±1.04)) and systolic and diastolic blood pressure Z scores (0.45 (±0.65) vs. 0.54 (±0.57); 0.91 (±0.66) vs. 0.96 (±0.57)) were similar, although elevated compared to the norm population. We also did not detect any differences between the groups in the other outcomes. In this study, we could not detect effects of a preconception lifestyle intervention in obese infertile women on the cardiometabolic health of their offspring. Low follow-up rates, perhaps due to the children’s age or the subject matter, combined with selection bias abating contrast in periconceptional weight between participating mothers, hampered the detection of potential effects. Future studies that account for these factors are needed to confirm whether a preconception lifestyle intervention may improve the cardiometabolic health of children of obese mothers.
KW - Cardiometabolic health
KW - Childhood obesity
KW - Follow-up
KW - Lifestyle intervention
KW - Maternal obesity
KW - Programming
UR - http://www.scopus.com/inward/record.url?scp=85122278302&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/cells11010041
DO - https://doi.org/10.3390/cells11010041
M3 - Article
C2 - 35011603
SN - 2073-4409
VL - 11
JO - Cells
JF - Cells
IS - 1
M1 - 41
ER -