TY - JOUR
T1 - The ENCODE project and perspectives on pathways
AU - Tragante, Vinicius
AU - Moore, Jason H.
AU - Asselbergs, Folkert W.
PY - 2014
Y1 - 2014
N2 - The recently completed ENCODE project is a new source of information on metabolic activity, unveiling knowledge about evolution and similarities among species, refuting the myth that most DNA is "junk" and has no actual function. With this expansive resource comes a challenge: integrating these new layers of information into our current knowledge of single-nucleotide polymorphisms and previously described metabolic pathways with the aim of discovering new genes and pathways related to human diseases and traits. Further, we must determine which computational methods will be most useful in this pursuit. In this paper, we speculate over the possible methods that will emerge in this new, challenging field. © 2014 WILEY PERIODICALS, INC.
AB - The recently completed ENCODE project is a new source of information on metabolic activity, unveiling knowledge about evolution and similarities among species, refuting the myth that most DNA is "junk" and has no actual function. With this expansive resource comes a challenge: integrating these new layers of information into our current knowledge of single-nucleotide polymorphisms and previously described metabolic pathways with the aim of discovering new genes and pathways related to human diseases and traits. Further, we must determine which computational methods will be most useful in this pursuit. In this paper, we speculate over the possible methods that will emerge in this new, challenging field. © 2014 WILEY PERIODICALS, INC.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84898681891&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/24723339
U2 - https://doi.org/10.1002/gepi.21802
DO - https://doi.org/10.1002/gepi.21802
M3 - Review article
C2 - 24723339
SN - 0741-0395
VL - 38
SP - 275
EP - 280
JO - Genetic epidemiology
JF - Genetic epidemiology
IS - 4
ER -