The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment

Katharina Brueggen; Michel J Grothe; Martin Dyrba; Andreas Fellgiebel; Florian Fischer; Massimo Filippi; Federica Agosta; Peter Nestor; Eva Meisenzahl; Janusch Blautzik; Lutz Frölich; Lucrezia Hausner; Arun L W Bokde; Giovanni Frisoni; Michela Pievani; Stefan Klöppel; David Prvulovic; Frederik Barkhof; Petra J W Pouwels; Johannes Schröder; Harald Hampel; Karlheinz Hauenstein; Stefan Teipel

doi:https://doi.org/10.1016/j.neuroimage.2016.03.067

The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment

Katharina Brueggen, Michel J Grothe, Martin Dyrba, Andreas Fellgiebel, Florian Fischer, Massimo Filippi, Federica Agosta, Peter Nestor, Eva Meisenzahl, Janusch Blautzik, Lutz Frölich, Lucrezia Hausner, Arun L W Bokde, Giovanni Frisoni, Michela Pievani, Stefan Klöppel, David Prvulovic, Frederik Barkhof, Petra J W Pouwels, Johannes SchröderHarald Hampel, Karlheinz Hauenstein, Stefan Teipel

Research output: Contribution to journal › Article › Academic › peer-review

20 Citations (Scopus)

Abstract

The European DTI Study on Dementia (EDSD) is a multicenter framework created to study the diagnostic accuracy and inter-site variability of DTI-derived markers in patients with manifest and prodromal Alzheimer's disease (AD). The dynamically growing database presently includes 493 DTI, 512 T1-weighted MRI, and 300 FLAIR scans from patients with AD dementia, patients with Mild Cognitive Impairment (MCI) and matched Healthy Controls, acquired on 13 different scanner platforms. The imaging data is publicly available, along with the subjects' demographic and clinical characterization. Detailed neuropsychological information, cerebrospinal fluid information on biomarkers and clinical follow-up diagnoses are included for a subset of subjects. This paper describes the rationale and structure of the EDSD, summarizes the available data, and explains how to gain access to the database. The EDSD is a useful database for researchers seeking to investigate the contribution of DTI to dementia diagnostics.

Original language	English
Pages (from-to)	305-308
Number of pages	4
Journal	NEUROIMAGE
Volume	144
Issue number	Pt B
DOIs	https://doi.org/10.1016/j.neuroimage.2016.03.067
Publication status	Published - Jan 2017

Keywords

Aged
Aged, 80 and over
Alzheimer Disease
Cognitive Dysfunction
Databases, Factual
Diffusion Tensor Imaging
Female
Humans
Information Dissemination
Journal Article
Male
Middle Aged
Multicenter Study

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https://doi.org/10.1016/j.neuroimage.2016.03.067

Cite this

Brueggen, K., Grothe, M. J., Dyrba, M., Fellgiebel, A., Fischer, F., Filippi, M., Agosta, F., Nestor, P., Meisenzahl, E., Blautzik, J., Frölich, L., Hausner, L., Bokde, A. L. W., Frisoni, G., Pievani, M., Klöppel, S., Prvulovic, D., Barkhof, F., Pouwels, P. J. W., ... Teipel, S. (2017). The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment. NEUROIMAGE, 144(Pt B), 305-308. https://doi.org/10.1016/j.neuroimage.2016.03.067

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title = "The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment",

abstract = "The European DTI Study on Dementia (EDSD) is a multicenter framework created to study the diagnostic accuracy and inter-site variability of DTI-derived markers in patients with manifest and prodromal Alzheimer's disease (AD). The dynamically growing database presently includes 493 DTI, 512 T1-weighted MRI, and 300 FLAIR scans from patients with AD dementia, patients with Mild Cognitive Impairment (MCI) and matched Healthy Controls, acquired on 13 different scanner platforms. The imaging data is publicly available, along with the subjects' demographic and clinical characterization. Detailed neuropsychological information, cerebrospinal fluid information on biomarkers and clinical follow-up diagnoses are included for a subset of subjects. This paper describes the rationale and structure of the EDSD, summarizes the available data, and explains how to gain access to the database. The EDSD is a useful database for researchers seeking to investigate the contribution of DTI to dementia diagnostics.",

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year = "2017",

month = jan,

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Brueggen, K, Grothe, MJ, Dyrba, M, Fellgiebel, A, Fischer, F, Filippi, M, Agosta, F, Nestor, P, Meisenzahl, E, Blautzik, J, Frölich, L, Hausner, L, Bokde, ALW, Frisoni, G, Pievani, M, Klöppel, S, Prvulovic, D, Barkhof, F , Pouwels, PJW, Schröder, J, Hampel, H, Hauenstein, K & Teipel, S 2017, 'The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment', NEUROIMAGE, vol. 144, no. Pt B, pp. 305-308. https://doi.org/10.1016/j.neuroimage.2016.03.067

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AU - Brueggen, Katharina

AU - Grothe, Michel J

AU - Dyrba, Martin

AU - Fellgiebel, Andreas

AU - Fischer, Florian

AU - Filippi, Massimo

AU - Agosta, Federica

AU - Nestor, Peter

AU - Meisenzahl, Eva

AU - Blautzik, Janusch

AU - Frölich, Lutz

AU - Hausner, Lucrezia

AU - Bokde, Arun L W

AU - Frisoni, Giovanni

AU - Pievani, Michela

AU - Klöppel, Stefan

AU - Prvulovic, David

AU - Barkhof, Frederik

AU - Pouwels, Petra J W

AU - Schröder, Johannes

AU - Hampel, Harald

AU - Hauenstein, Karlheinz

AU - Teipel, Stefan

PY - 2017/1

Y1 - 2017/1

N2 - The European DTI Study on Dementia (EDSD) is a multicenter framework created to study the diagnostic accuracy and inter-site variability of DTI-derived markers in patients with manifest and prodromal Alzheimer's disease (AD). The dynamically growing database presently includes 493 DTI, 512 T1-weighted MRI, and 300 FLAIR scans from patients with AD dementia, patients with Mild Cognitive Impairment (MCI) and matched Healthy Controls, acquired on 13 different scanner platforms. The imaging data is publicly available, along with the subjects' demographic and clinical characterization. Detailed neuropsychological information, cerebrospinal fluid information on biomarkers and clinical follow-up diagnoses are included for a subset of subjects. This paper describes the rationale and structure of the EDSD, summarizes the available data, and explains how to gain access to the database. The EDSD is a useful database for researchers seeking to investigate the contribution of DTI to dementia diagnostics.

AB - The European DTI Study on Dementia (EDSD) is a multicenter framework created to study the diagnostic accuracy and inter-site variability of DTI-derived markers in patients with manifest and prodromal Alzheimer's disease (AD). The dynamically growing database presently includes 493 DTI, 512 T1-weighted MRI, and 300 FLAIR scans from patients with AD dementia, patients with Mild Cognitive Impairment (MCI) and matched Healthy Controls, acquired on 13 different scanner platforms. The imaging data is publicly available, along with the subjects' demographic and clinical characterization. Detailed neuropsychological information, cerebrospinal fluid information on biomarkers and clinical follow-up diagnoses are included for a subset of subjects. This paper describes the rationale and structure of the EDSD, summarizes the available data, and explains how to gain access to the database. The EDSD is a useful database for researchers seeking to investigate the contribution of DTI to dementia diagnostics.

KW - Aged

KW - Aged, 80 and over

KW - Alzheimer Disease

KW - Cognitive Dysfunction

KW - Databases, Factual

KW - Diffusion Tensor Imaging

KW - Female

KW - Humans

KW - Information Dissemination

KW - Journal Article

KW - Male

KW - Middle Aged

KW - Multicenter Study

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DO - https://doi.org/10.1016/j.neuroimage.2016.03.067

M3 - Article

C2 - 27046114

SN - 1053-8119

VL - 144

SP - 305

EP - 308

JO - NEUROIMAGE

JF - NEUROIMAGE

IS - Pt B

ER -