TY - JOUR
T1 - The Genetic Architectures of Functional and Structural Connectivity Properties within Cerebral Resting-State Networks
AU - Tissink, Elleke
AU - Werme, Josefin
AU - de Lange, Siemon C.
AU - Savage, Jeanne E.
AU - Wei, Yongbin
AU - de Leeuw, Christiaan A.
AU - Nagel, Mats
AU - Posthuma, Danielle
AU - van den Heuvel, Martijn P.
N1 - Funding Information: D.P. was supported by The Netherlands Organization for Scientific Research (NWO) Grant VICI 453-14-005, the NWO Gravitation: BRAINSCAPES: A Roadmap from Neurogenetics to Neurobiology Grant No. 024.004.012, and the European Research Council (ERC) Advanced Grant No. ERC-2018-AdG GWAS2FUNC 834057. The work of S.C.d.L. was supported by the ZonMw Open Competition Project REMOVE 09120011910032. C.A.d.L. is supported by Hoffman-La Roche. M.P.v.d.H. was supported by NWO VIDI Grant 452-16-015 and the ERC Consolidator of the European Research Council Grant 101001062. J.E.S. was supported by the NWO VENI Grant 201G-064. Publisher Copyright: © 2023 Tissink et al.
PY - 2023/4/1
Y1 - 2023/4/1
N2 - Functional connectivity within resting-state networks (RSN-FC) is vital for cognitive functioning. RSN-FC is her-itable and partially translates to the anatomic architecture of white matter, but the genetic component of structural connections of RSNs (RSN-SC) and their potential genetic overlap with RSN-FC remain unknown. Here, we perform genome-wide association studies (Ndiscovery = 24,336; Nreplication = 3412) and annotation on RSN-SC and RSN-FC. We identify genes for visual network-SC that are involved in axon guidance and synaptic functioning. Genetic variation in RSN-FC impacts biological processes relevant to brain disorders that previ-ously were only phenotypically associated with RSN-FC alterations. Correlations of the genetic components of RSNs are mostly observed within the functional domain, whereas less overlap is observed within the structural domain and between the functional and structural domains. This study advances the understanding of the complex functional organization of the brain and its structural underpinnings from a genetics viewpoint.
AB - Functional connectivity within resting-state networks (RSN-FC) is vital for cognitive functioning. RSN-FC is her-itable and partially translates to the anatomic architecture of white matter, but the genetic component of structural connections of RSNs (RSN-SC) and their potential genetic overlap with RSN-FC remain unknown. Here, we perform genome-wide association studies (Ndiscovery = 24,336; Nreplication = 3412) and annotation on RSN-SC and RSN-FC. We identify genes for visual network-SC that are involved in axon guidance and synaptic functioning. Genetic variation in RSN-FC impacts biological processes relevant to brain disorders that previ-ously were only phenotypically associated with RSN-FC alterations. Correlations of the genetic components of RSNs are mostly observed within the functional domain, whereas less overlap is observed within the structural domain and between the functional and structural domains. This study advances the understanding of the complex functional organization of the brain and its structural underpinnings from a genetics viewpoint.
KW - GWAS
KW - connectivity
KW - networks
KW - neuroimaging
KW - resting-state
KW - structure-function
UR - http://www.scopus.com/inward/record.url?scp=85152170371&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85152170371&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85152170371&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36882310
U2 - https://doi.org/10.1523/ENEURO.0242-22.2023
DO - https://doi.org/10.1523/ENEURO.0242-22.2023
M3 - Article
C2 - 36882310
SN - 2373-2822
VL - 10
SP - 1
EP - 16
JO - eNeuro
JF - eNeuro
IS - 4
M1 - ENEURO.0242-22.2023
ER -