TY - JOUR
T1 - The global meningitis genome partnership
AU - Rodgers, Elizabeth
AU - Bentley, Stephen D.
AU - Borrow, Ray
AU - Bratcher, Holly B.
AU - Brisse, Sylvain
AU - Brueggemann, Angela B.
AU - Caugant, Dominique A.
AU - Findlow, Jamie
AU - Fox, LeAnne
AU - Glennie, Linda
AU - Harrison, Lee H.
AU - Harrison, Odile B.
AU - Heyderman, Robert S.
AU - van Rensburg, Melissa Jansen
AU - Jolley, Keith A.
AU - Kwambana-Adams, Brenda
AU - Ladhani, Shamez
AU - LaForce, Marc
AU - Levin, Michael
AU - Lucidarme, Jay
AU - MacAlasdair, Neil
AU - Maclennan, Jenny
AU - Maiden, Martin C. J.
AU - Maynard-Smith, Laura
AU - Muzzi, Alessandro
AU - Oster, Philipp
AU - Rodrigues, Charlene M. C.
AU - Ronveaux, Olivier
AU - Serino, Laura
AU - Smith, Vinny
AU - van der Ende, Arie
AU - Vázquez, Julio
AU - Wang, Xin
AU - Yezli, Saber
AU - Stuart, James M.
PY - 2020/10
Y1 - 2020/10
N2 - Genomic surveillance of bacterial meningitis pathogens is essential for effective disease control globally, enabling identification of emerging and expanding strains and consequent public health interventions. While there has been a rise in the use of whole genome sequencing, this has been driven predominately by a subset of countries with adequate capacity and resources. Global capacity to participate in surveillance needs to be expanded, particularly in low and middle-income countries with high disease burdens. In light of this, the WHO-led collaboration, Defeating Meningitis by 2030 Global Roadmap, has called for the establishment of a Global Meningitis Genome Partnership that links resources for: N. meningitidis (Nm), S. pneumoniae (Sp), H. influenzae (Hi) and S. agalactiae (Sa) to improve worldwide co-ordination of strain identification and tracking. Existing platforms containing relevant genomes include: PubMLST: Nm (31,622), Sp (15,132), Hi (1935), Sa (9026); The Wellcome Sanger Institute: Nm (13,711), Sp (> 24,000), Sa (6200), Hi (1738); and BMGAP: Nm (8785), Hi (2030). A steering group is being established to coordinate the initiative and encourage high-quality data curation. Next steps include: developing guidelines on open-access sharing of genomic data; defining a core set of metadata; and facilitating development of user-friendly interfaces that represent publicly available data.
AB - Genomic surveillance of bacterial meningitis pathogens is essential for effective disease control globally, enabling identification of emerging and expanding strains and consequent public health interventions. While there has been a rise in the use of whole genome sequencing, this has been driven predominately by a subset of countries with adequate capacity and resources. Global capacity to participate in surveillance needs to be expanded, particularly in low and middle-income countries with high disease burdens. In light of this, the WHO-led collaboration, Defeating Meningitis by 2030 Global Roadmap, has called for the establishment of a Global Meningitis Genome Partnership that links resources for: N. meningitidis (Nm), S. pneumoniae (Sp), H. influenzae (Hi) and S. agalactiae (Sa) to improve worldwide co-ordination of strain identification and tracking. Existing platforms containing relevant genomes include: PubMLST: Nm (31,622), Sp (15,132), Hi (1935), Sa (9026); The Wellcome Sanger Institute: Nm (13,711), Sp (> 24,000), Sa (6200), Hi (1738); and BMGAP: Nm (8785), Hi (2030). A steering group is being established to coordinate the initiative and encourage high-quality data curation. Next steps include: developing guidelines on open-access sharing of genomic data; defining a core set of metadata; and facilitating development of user-friendly interfaces that represent publicly available data.
KW - Bacterial meningitis
KW - Epidemiology
KW - Genome partnership
KW - Haemophilus influenzae
KW - Neisseria meningitidis
KW - Streptococcus agalactiae
KW - Streptococcus pneumoniae
KW - Whole genome sequencing
UR - http://www.scopus.com/inward/record.url?scp=85087667266&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jinf.2020.06.064
DO - https://doi.org/10.1016/j.jinf.2020.06.064
M3 - Article
C2 - 32615197
SN - 0163-4453
VL - 81
SP - 510
EP - 520
JO - Journal of Infection
JF - Journal of Infection
IS - 4
ER -