The growth-associated protein B-50 (GAP-43) in dystrophic neurites extending into Alzheimer's plaques

A. B. Oestreicher, J. M. Rozemuller, W. H. Gispen

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Abstract

The expression of the growth associated protein B-50 (GAP-43) is developmentally regulated and reinduced following neuronal injury. Using B-50 as marker for sprouting in single and double immunolabeling of neocortex of Alzheimer's disease (AD) we demonstrate that bulbous B-50 immunoreactive dystrophic neurites are found in β-amyloid/A4 positive plaques. Our results and those of others indicate that dystrophic neurites contain B-50 implicating this protein in the disease induced response.

Original languageEnglish
JournalNEUROSCIENCE RESEARCH COMMUNICATIONS
Volume12
Issue numberSUPPL. 1
Publication statusPublished - 1 Jan 1993

Keywords

  • Dystrophic neurites
  • Growth-associated proteins
  • Neuritic plaques
  • β-amyloid/A4 protein

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