TY - JOUR
T1 - The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes
AU - Aydin, Ömrüm
AU - Nieuwdorp, Max
AU - Gerdes, Victor
PY - 2018
Y1 - 2018
N2 - Purpose of Review: The objective of this review is to critically assess the contributing role of the gut microbiota in human obesity and type 2 diabetes (T2D). Recent Findings: Experiments in animal and human studies have produced growing evidence for the causality of the gut microbiome in developing obesity and T2D. The introduction of high-throughput sequencing technologies has provided novel insight into the interpersonal differences in microbiome composition and function. Summary: The intestinal microbiota is known to be associated with metabolic syndrome and related comorbidities. Associated diseases including obesity, T2D, and fatty liver disease (NAFLD/NASH) all seem to be linked to altered microbial composition; however, causality has not been proven yet. Elucidating the potential causal and personalized role of the human gut microbiota in obesity and T2D is highly prioritized.
AB - Purpose of Review: The objective of this review is to critically assess the contributing role of the gut microbiota in human obesity and type 2 diabetes (T2D). Recent Findings: Experiments in animal and human studies have produced growing evidence for the causality of the gut microbiome in developing obesity and T2D. The introduction of high-throughput sequencing technologies has provided novel insight into the interpersonal differences in microbiome composition and function. Summary: The intestinal microbiota is known to be associated with metabolic syndrome and related comorbidities. Associated diseases including obesity, T2D, and fatty liver disease (NAFLD/NASH) all seem to be linked to altered microbial composition; however, causality has not been proven yet. Elucidating the potential causal and personalized role of the human gut microbiota in obesity and T2D is highly prioritized.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85050296764&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29931613
U2 - https://doi.org/10.1007/s11892-018-1020-6
DO - https://doi.org/10.1007/s11892-018-1020-6
M3 - Review article
C2 - 29931613
SN - 1534-4827
VL - 18
JO - Current Diabetes Reports
JF - Current Diabetes Reports
IS - 8
M1 - 55
ER -