TY - JOUR
T1 - The hepatitis C epidemic among HIV-positive MSM: incidence estimates from 1990 to 2007
AU - van der Helm, Jannie J.
AU - Prins, Maria
AU - del Amo, Julia
AU - Bucher, Heiner C.
AU - Chêne, Geneviève
AU - Dorrucci, Maria
AU - Gill, John
AU - Hamouda, Osamah
AU - Sannes, Mette
AU - Porter, Kholoud
AU - Geskus, Ronald B.
AU - AUTHOR GROUP
AU - Meyer, Laurence
AU - Pillay, Deenan
AU - Rosinska, Magda
AU - Sabin, Caroline
AU - Touloumi, Giota
AU - Lodi, Sara
AU - Coughlin, Kate
AU - Walker, Sarah
AU - Babiker, Abdel
AU - de Luca, Andrea
AU - Fisher, Martin
AU - Muga, Roberto
AU - Zangerle, Robert
AU - Kelleher, Tony
AU - Ramacciotti, Tim
AU - Gelgor, Linda
AU - Cooper, David
AU - Smith, Don
AU - Bruun Jørgensen, Louise
AU - Nielsen, Claus
AU - Pedersen, Court
AU - Lutsar, Irja
AU - Dabis, Francois
AU - Thiebaut, Rodolphe
AU - Masquelier, Bernard
AU - Costagliola, Dominique
AU - Guiguet, Marguerite
AU - Vanhems, Philippe
AU - Chaix, Marie-Laure
AU - Ghosn, Jade
AU - Boufassa, Faroudy
AU - Kücherer, Claudia
AU - Bartmeyer, Barbara
AU - Pantazis, Nikos
AU - Hatzakis, Angelos
AU - Paraskevis, Dimitrios
AU - Karafoulidou, Anastasia
AU - Rezza, Giovanni
AU - Schuitemaker, Hanneke
PY - 2011
Y1 - 2011
N2 - Outbreaks of acute hepatitis C virus (HCV) infection among HIV-infected MSM have been described since 2000. However, phylogenetic analysis suggests that the spread of HCV started around 1996. We estimated the incidence of HCV in HIV-infected MSM with well estimated dates of HIV seroconversion from 1990 to 2007. Data from 12 cohorts within the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) Collaboration were used. HCV incidence was estimated using standard incidence methods and methods for interval-censored data. We accounted for the fact that routine HCV data collection in each cohort started in different calendar years. Of 4724 MSM, 3014 had an HCV test result and were included. Of these, 124 (4%) had only positive HCV test results, 2798 (93%) had only negative results and 92 (3%) had both. In 1990, HCV incidence ranged from 0.9 to 2.2 per 1000 person-years, depending on the analysis strategy used. HCV incidence increased up to 1995 when it was estimated to range between 5.5 and 8.1 per 1000 person-years. From 2002 onwards, it increased substantially to values between 16.8 and 30.0 per 1000 person-years in 2005 and between 23.4 and 51.1 per 1000 person-years in 2007. Our data support phylodynamic findings that HCV incidence had already increased among HIV-infected MSM from the mid-1990s. However, the main expansion of the HCV epidemic started after 2002. Incidence estimates obtained from cohort studies may help identify changes in the spread of important infections earlier and should guide routine testing policies to minimize further disease burden
AB - Outbreaks of acute hepatitis C virus (HCV) infection among HIV-infected MSM have been described since 2000. However, phylogenetic analysis suggests that the spread of HCV started around 1996. We estimated the incidence of HCV in HIV-infected MSM with well estimated dates of HIV seroconversion from 1990 to 2007. Data from 12 cohorts within the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) Collaboration were used. HCV incidence was estimated using standard incidence methods and methods for interval-censored data. We accounted for the fact that routine HCV data collection in each cohort started in different calendar years. Of 4724 MSM, 3014 had an HCV test result and were included. Of these, 124 (4%) had only positive HCV test results, 2798 (93%) had only negative results and 92 (3%) had both. In 1990, HCV incidence ranged from 0.9 to 2.2 per 1000 person-years, depending on the analysis strategy used. HCV incidence increased up to 1995 when it was estimated to range between 5.5 and 8.1 per 1000 person-years. From 2002 onwards, it increased substantially to values between 16.8 and 30.0 per 1000 person-years in 2005 and between 23.4 and 51.1 per 1000 person-years in 2007. Our data support phylodynamic findings that HCV incidence had already increased among HIV-infected MSM from the mid-1990s. However, the main expansion of the HCV epidemic started after 2002. Incidence estimates obtained from cohort studies may help identify changes in the spread of important infections earlier and should guide routine testing policies to minimize further disease burden
U2 - https://doi.org/10.1097/QAD.0b013e3283471cce
DO - https://doi.org/10.1097/QAD.0b013e3283471cce
M3 - Article
C2 - 21537114
SN - 0269-9370
VL - 25
SP - 1083
EP - 1091
JO - AIDS (London, England)
JF - AIDS (London, England)
IS - 8
ER -