TY - JOUR
T1 - The heritability of doctor-diagnosed traumatic and degenerative meniscus tears
AU - Magnusson, K.
AU - Turkiewicz, A.
AU - Snoeker, B.
AU - Hughes, V.
AU - Englund, M.
N1 - Funding Information: We declare no conflicts of interest, except for Dr. Englund receiving grants from the Swedish Research Council , the Österlund Foundation, Governmental Funding of Clinical Research within National Health Service (ALF), the Greta and Johan Kock Foundation, and the Swedish Rheumatism Association , during the conduct of the study. Funding Information: We would like to acknowledge The Swedish Twin Registry and Barbro Sandin and Patrik Magnusson for access to the data and data management. The Swedish Twin Registry is managed by Karolinska Institute and receives funding through the Swedish Research Council under grant no. 2017-00641 . The study was funded by the Swedish Research Council ( E0234801 ), the Greta and Johan Kock Foundation , the Swedish Rheumatism Association , the Österlund Foundation, Governmental Funding of Clinical Research within National Health Service (ALF) and the Faculty of Medicine, Lund University, Sweden. Publisher Copyright: © 2021 The Authors
PY - 2021/7
Y1 - 2021/7
N2 - Objective: To estimate the genetic contribution to traumatic and degenerative meniscus tears for men and women across the lifespan. Methods: We linked the Swedish Twin Register with individual-level national healthcare data to form a 30-year, population-wide, longitudinal twin cohort. To study genetic contribution to meniscus tears, we estimated the heritability and familial risk using incident traumatic and degenerative tear diagnostic codes in a cohort of 88,414 monozygotic and dizygotic twin-pairs, aged ≥17 years. Results: During follow-up, 3,372 (3.8%) of 88,414 twins were diagnosed with a traumatic or degenerative meniscus tear. The heritability was 0.39 (95% CI = 0.32–0.47) for men and 0.43 (95% CI = 0.36–0.50) for women, and did not vary by age. Environmental factors that were unique to each twin in a pair explained a greater proportion of the variance than genetic factors, both for men (0.61, 95% CI = 0.53–0.68) and women (0.57, 95% CI = 0.50–0.64). Separate analyses of traumatic vs degenerative meniscus tears yielded similar results. Conclusion: For the first time, we have estimated the genetic contribution to doctor-diagnosed meniscus tears using a twin study design. We found a relatively low to modest heritability for meniscus tears (∼40%). The heritability was also fairly stable over the lifespan, and equal in both men and women. Our findings suggest that environmental risk factors are a more important contributor to both traumatic and degenerative doctor-diagnosed meniscus tears than genetic factors.
AB - Objective: To estimate the genetic contribution to traumatic and degenerative meniscus tears for men and women across the lifespan. Methods: We linked the Swedish Twin Register with individual-level national healthcare data to form a 30-year, population-wide, longitudinal twin cohort. To study genetic contribution to meniscus tears, we estimated the heritability and familial risk using incident traumatic and degenerative tear diagnostic codes in a cohort of 88,414 monozygotic and dizygotic twin-pairs, aged ≥17 years. Results: During follow-up, 3,372 (3.8%) of 88,414 twins were diagnosed with a traumatic or degenerative meniscus tear. The heritability was 0.39 (95% CI = 0.32–0.47) for men and 0.43 (95% CI = 0.36–0.50) for women, and did not vary by age. Environmental factors that were unique to each twin in a pair explained a greater proportion of the variance than genetic factors, both for men (0.61, 95% CI = 0.53–0.68) and women (0.57, 95% CI = 0.50–0.64). Separate analyses of traumatic vs degenerative meniscus tears yielded similar results. Conclusion: For the first time, we have estimated the genetic contribution to doctor-diagnosed meniscus tears using a twin study design. We found a relatively low to modest heritability for meniscus tears (∼40%). The heritability was also fairly stable over the lifespan, and equal in both men and women. Our findings suggest that environmental risk factors are a more important contributor to both traumatic and degenerative doctor-diagnosed meniscus tears than genetic factors.
KW - Acute meniscus tears
KW - Degenerative meniscus tears
KW - Epidemiology
KW - Genetics
KW - Meniscus tears
UR - http://www.scopus.com/inward/record.url?scp=85104068432&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.joca.2021.03.005
DO - https://doi.org/10.1016/j.joca.2021.03.005
M3 - Article
C2 - 33744431
SN - 1063-4584
VL - 29
SP - 979
EP - 985
JO - Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
JF - Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
IS - 7
ER -