TY - JOUR
T1 - The Hospitalization Rate of Cerebral Venous Sinus Thrombosis before and during COVID-19 Pandemic Era
T2 - A Single-Center Retrospective Cohort Study
AU - Vasaghi Gharamaleki, Maryam
AU - Habibagahi, Maryam
AU - Hooshmandi, Etrat
AU - Tabrizi, Reza
AU - Arsang-Jang, Shahram
AU - Barzegar, Zohreh
AU - Fadakar, Nima
AU - Reza Ostovan, Vahid
AU - Rahimi-Jaberi, Abbas
AU - Ashjazadeh, Nahid
AU - Petramfar, Peyman
AU - Poursadeghfard, Maryam
AU - Izadi, Sadegh
AU - Nazeri, Masoumeh
AU - Bazrafshan, Hanieh
AU - Bahrami, Zahra
AU - Karimlu, Sedigheh
AU - Shaghayegh Zafarmand, Seyedeh
AU - Bayat, Mahnaz
AU - Saied Salehi, Mohammad
AU - Owjfard, Maryam
AU - Karimi-Haghighi, Saeideh
AU - Safari, Anahid
AU - Shakibajahromi, Banafsheh
AU - Lim Alvin Chew, Beng
AU - Worral, Bradford B. g
AU - Coutinho, Jonathan M.
AU - Garcia-Esperon, Carlos
AU - Spratt, Neil
AU - Levi, Christopher
AU - Azarpazhooh, Mahmoud Reza
AU - Borhani-Haghighi, Afshin
N1 - Funding Information: This study is financially supported by the Office of Vice Chancellor for Research in Shiraz University of Medical Sciences (Grant No.: 19434). Funding Information: The authors would like to thank the Vice-Chancellor of Treatment Affairs of Shiraz University of Medical Sciences for their assistance. Publisher Copyright: © 2022 Elsevier Inc.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Objectives: There are several reports of the association between SARS-CoV-2 infection (COVID-19) and cerebral venous sinus thrombosis (CVST). In this study, we aimed to compare the hospitalization rate of CVST before and during the COVID-19 pandemic (before vaccination program). Materials and methods: In this retrospective cohort study, the hospitalization rate of adult CVST patients in Namazi hospital, a tertiary referral center in the south of Iran, was compared in two periods of time. We defined March 2018 to March 2019 as the pre-COVID-19 period and March 2020 to March 2021 as the COVID-19 period. Results: 50 and 77 adult CVST patients were hospitalized in the pre-COVID-19 and COVID-19 periods, respectively. The crude CVST hospitalization rate increased from 14.33 in the pre-COVID-19 period to 21.7 per million in the COVID-19 era (P = 0.021). However, after age and sex adjustment, the incremental trend in hospitalization rate was not significant (95% CrI: -2.2, 5.14). Patients > 50-year-old were more often hospitalized in the COVID-19 period (P = 0.042). SARS-CoV-2 PCR test was done in 49.3% out of all COVID-19 period patients, which were positive in 6.5%. Modified Rankin Scale (mRS) score ≥3 at three-month follow-up was associated with age (P = 0.015) and malignancy (P = 0.014) in pre-COVID period; and was associated with age (P = 0.025), altered mental status on admission time (P<0.001), malignancy (P = 0.041) and COVID-19 infection (P = 0.008) in COVID-19 period. Conclusion: Since there was a more dismal outcome in COVID-19 associated CVST, a high index of suspicion for CVST among COVID-19 positive is recommended.
AB - Objectives: There are several reports of the association between SARS-CoV-2 infection (COVID-19) and cerebral venous sinus thrombosis (CVST). In this study, we aimed to compare the hospitalization rate of CVST before and during the COVID-19 pandemic (before vaccination program). Materials and methods: In this retrospective cohort study, the hospitalization rate of adult CVST patients in Namazi hospital, a tertiary referral center in the south of Iran, was compared in two periods of time. We defined March 2018 to March 2019 as the pre-COVID-19 period and March 2020 to March 2021 as the COVID-19 period. Results: 50 and 77 adult CVST patients were hospitalized in the pre-COVID-19 and COVID-19 periods, respectively. The crude CVST hospitalization rate increased from 14.33 in the pre-COVID-19 period to 21.7 per million in the COVID-19 era (P = 0.021). However, after age and sex adjustment, the incremental trend in hospitalization rate was not significant (95% CrI: -2.2, 5.14). Patients > 50-year-old were more often hospitalized in the COVID-19 period (P = 0.042). SARS-CoV-2 PCR test was done in 49.3% out of all COVID-19 period patients, which were positive in 6.5%. Modified Rankin Scale (mRS) score ≥3 at three-month follow-up was associated with age (P = 0.015) and malignancy (P = 0.014) in pre-COVID period; and was associated with age (P = 0.025), altered mental status on admission time (P<0.001), malignancy (P = 0.041) and COVID-19 infection (P = 0.008) in COVID-19 period. Conclusion: Since there was a more dismal outcome in COVID-19 associated CVST, a high index of suspicion for CVST among COVID-19 positive is recommended.
KW - COVID-19
KW - Hospitalization rate
KW - Prognosis
KW - SARS-CoV-2
KW - Sinus thrombosis
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=85129690508&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106468
DO - https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106468
M3 - Article
C2 - 35523051
SN - 1052-3057
VL - 31
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
IS - 7
M1 - 106468
ER -