The human CMV-UL86 peptide 981-1003 shares a crossreactive T-cell epitope with the encephalitogenic MOG peptide 34-56, but lacks the capacity to induce EAE in rhesus monkeys

Herbert P M Brok, Leonie Boven, Marjan van Meurs, Nicole Kerlero de Rosbo, Liesbeth Celebi-Paul, Yolanda S Kap, Anwar Jagessar, Rogier Q Hintzen, Geoff Keir, Jeffrey Bajramovic, Avraham Ben-Nun, Jan Bauer, Jon D Laman, Sandra Amor, Bert A 't Hart

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)

Abstract

Rhesus monkeys immunized with MOG(34-56), a dominant T-cell epitope from myelin/oligodendrocyte glycoprotein, develop an acute neurological disease resembling acute disseminated encephalomyelitis (ADEM) in humans. The typical large demyelinated lesions and mononuclear infiltrates in the monkey brains are caused by MOG(34-56) T-cells. We show that MOG(34-56)-reactive CD4+ and CD8+ T-cells are induced in monkeys immunized with a peptide from the human CMV major capsid protein (UL86; 981-1003), that shares sequence similarity with MOG(34-56). Monkeys sensitized against the viral peptide and subsequently challenged with MOG(34-56) display histological signs of encephalitis, but do not show overt neurological signs.

Original languageEnglish
Pages (from-to)135-52
Number of pages18
JournalJournal of Neuroimmunology
Volume182
Issue number1-2
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Animals
  • Antibodies
  • Brain
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Capsid Proteins
  • Cell Line
  • Cell Proliferation
  • Cholesterol
  • Cross Reactions
  • Encephalomyelitis, Autoimmune, Experimental
  • Epitopes, T-Lymphocyte
  • Female
  • Glycoproteins
  • Humans
  • Journal Article
  • Lymphocyte Activation
  • Macaca mulatta
  • Male
  • Monocytes
  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Myelin-Oligodendrocyte Glycoprotein
  • Peptide Fragments
  • Polyethylene Glycols
  • Recombinant Proteins
  • Research Support, Non-U.S. Gov't
  • Spinal Cord

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