TY - JOUR
T1 - The immunopathology of sepsis and potential therapeutic targets
AU - van der Poll, Tom
AU - van de Veerdonk, Frank L.
AU - Scicluna, Brendon P.
AU - Netea, Mihai G.
PY - 2017
Y1 - 2017
N2 - Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. In sepsis, the immune response that is initiated by an invading pathogen fails to return to homeostasis, thus culminating in a pathological syndrome that is characterized by sustained excessive inflammation and immune suppression. Our understanding of the key mechanisms involved in the pathogenesis of sepsis has increased tremendously, yet this still needs to be translated into novel targeted therapeutic strategies. Pivotal for the clinical development of new sepsis therapies is the selection of patients on the basis of biomarkers and/or functional defects that provide specific insights into the expression or activity of the therapeutic target
AB - Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. In sepsis, the immune response that is initiated by an invading pathogen fails to return to homeostasis, thus culminating in a pathological syndrome that is characterized by sustained excessive inflammation and immune suppression. Our understanding of the key mechanisms involved in the pathogenesis of sepsis has increased tremendously, yet this still needs to be translated into novel targeted therapeutic strategies. Pivotal for the clinical development of new sepsis therapies is the selection of patients on the basis of biomarkers and/or functional defects that provide specific insights into the expression or activity of the therapeutic target
U2 - https://doi.org/10.1038/nri.2017.36
DO - https://doi.org/10.1038/nri.2017.36
M3 - Review article
C2 - 28436424
SN - 1474-1733
VL - 17
SP - 407
EP - 420
JO - Nature Reviews. Immunology
JF - Nature Reviews. Immunology
IS - 7
ER -