TY - JOUR
T1 - The impact of obstructive sleep apnea on endothelial function during weight loss in an obese pediatric population
AU - Jacobs, Sofie
AU - Mylemans, Emilie
AU - Ysebaert, Marijke
AU - Vermeiren, Eline
AU - de Guchtenaere, Ann
AU - Heuten, Hilde
AU - Bruyndoncx, Luc
AU - de Winter, Benedicte Y.
AU - van Hoorenbeeck, Kim
AU - Verhulst, Stijn L.
AU - van Eyck, Annelies
N1 - Funding Information: This research was made possible with financial support from the ‘ Research Foundation Flanders ’, FWO-TBM project number 150179 . Publisher Copyright: © 2021 Elsevier B.V. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Background: Childhood obesity is an increasing problem with substantial comorbidities such as obstructive sleep apnea (OSA) and increased cardiovascular morbidity. Endothelial dysfunction is an underlying mechanism related to both obesity and OSA. Research question: To investigate the effect of weight loss on endothelial function and OSA in obese children and to determine whether a change in endothelial function can be linked to an improvement in OSA. Methods: Obese children between 8 and 18 years of age were recruited while entering a 12-month inpatient weight loss program. Patients were followed at 3 study visits: baseline, after 10 months of weight loss, and 6 months after ending the program (18 months). Anthropometry and endothelial function (EndoPAT) were determined at all study visits. At baseline, sleep screening with a portable device (ApneaLink) was performed. This was repeated after 10 months if OSA was diagnosed at baseline. Results: At baseline, 130 children were included, of which 87 had OSA (67%). Seventy-two patients attended the follow-up visit at 10 months, and 28 patients attended the follow-up visit at 18 months. The BMI z-score decreased after 10 months (from 2.7 (1.4–3.4) to 1.7 (0.5–2.7); p < 0.001) and remained stable at 18 months. Endothelial function improved significantly after weight loss, evidenced by a shorter time to peak response (TPR) and higher reactive hyperemia index (p = 0.02 and p < 0.001), and remained improved after 18 months (p < 0.001 and p = 0.007). After 10 months of weight loss, 10 patients had residual OSA. These patients had a higher TPR at 10 months (225 (75–285)s) than those without OSA (135 (45–225)s) and patients with a normalized sleep study (105 (45–285)s; p = 0.02). Linear mixed models showed that more severe OSA was associated with a worse TPR at baseline and less improvement after weight loss. Conclusion: Weight loss improves endothelial function in an obese pediatric population. However, even after weight loss, endothelial function improved less in the presence of OSA.
AB - Background: Childhood obesity is an increasing problem with substantial comorbidities such as obstructive sleep apnea (OSA) and increased cardiovascular morbidity. Endothelial dysfunction is an underlying mechanism related to both obesity and OSA. Research question: To investigate the effect of weight loss on endothelial function and OSA in obese children and to determine whether a change in endothelial function can be linked to an improvement in OSA. Methods: Obese children between 8 and 18 years of age were recruited while entering a 12-month inpatient weight loss program. Patients were followed at 3 study visits: baseline, after 10 months of weight loss, and 6 months after ending the program (18 months). Anthropometry and endothelial function (EndoPAT) were determined at all study visits. At baseline, sleep screening with a portable device (ApneaLink) was performed. This was repeated after 10 months if OSA was diagnosed at baseline. Results: At baseline, 130 children were included, of which 87 had OSA (67%). Seventy-two patients attended the follow-up visit at 10 months, and 28 patients attended the follow-up visit at 18 months. The BMI z-score decreased after 10 months (from 2.7 (1.4–3.4) to 1.7 (0.5–2.7); p < 0.001) and remained stable at 18 months. Endothelial function improved significantly after weight loss, evidenced by a shorter time to peak response (TPR) and higher reactive hyperemia index (p = 0.02 and p < 0.001), and remained improved after 18 months (p < 0.001 and p = 0.007). After 10 months of weight loss, 10 patients had residual OSA. These patients had a higher TPR at 10 months (225 (75–285)s) than those without OSA (135 (45–225)s) and patients with a normalized sleep study (105 (45–285)s; p = 0.02). Linear mixed models showed that more severe OSA was associated with a worse TPR at baseline and less improvement after weight loss. Conclusion: Weight loss improves endothelial function in an obese pediatric population. However, even after weight loss, endothelial function improved less in the presence of OSA.
KW - Endothelium
KW - Obesity
KW - Obstructive sleep apnea
KW - Pediatrics
KW - Sleep-disordered breathing
KW - Weight loss
UR - http://www.scopus.com/inward/record.url?scp=85113498759&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.sleep.2021.08.002
DO - https://doi.org/10.1016/j.sleep.2021.08.002
M3 - Article
C2 - 34461597
SN - 1389-9457
VL - 86
SP - 48
EP - 55
JO - Sleep Medicine
JF - Sleep Medicine
ER -