TY - JOUR
T1 - The incretin pathway as a therapeutic target in diabetic kidney disease: a clinical focus on GLP-1 receptor agonists
AU - van Baar, Michaël J. B.
AU - van der Aart, Annemarie B.
AU - Hoogenberg, Klaas
AU - Joles, Jaap A.
AU - Heerspink, Hiddo J. L.
AU - van Raalte, Daniël H.
PY - 2019
Y1 - 2019
N2 - Diabetic kidney disease (DKD) remains the main cause for chronic kidney disease (CKD) and end-stage kidney disease (ESKD) worldwide. Both CKD and ESKD lead to major increases in risk of cardiovascular disease and death in people with diabetes. Despite optimal management of lifestyle, glucose levels and hypertension, residual risk remains high, indicating that additional therapies to mitigate the burden of the disease are desired. In past decades, new treatment options for the management of diabetes have emerged, of which some have showed promising renoprotective potential. This review discusses current understanding of the renal effects of glucagon-like peptide receptor agonists and their potential use in prevention and treatment of DKD.
AB - Diabetic kidney disease (DKD) remains the main cause for chronic kidney disease (CKD) and end-stage kidney disease (ESKD) worldwide. Both CKD and ESKD lead to major increases in risk of cardiovascular disease and death in people with diabetes. Despite optimal management of lifestyle, glucose levels and hypertension, residual risk remains high, indicating that additional therapies to mitigate the burden of the disease are desired. In past decades, new treatment options for the management of diabetes have emerged, of which some have showed promising renoprotective potential. This review discusses current understanding of the renal effects of glucagon-like peptide receptor agonists and their potential use in prevention and treatment of DKD.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075116981&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31384419
U2 - https://doi.org/10.1177/2042018819865398
DO - https://doi.org/10.1177/2042018819865398
M3 - Review article
C2 - 31384419
SN - 2042-0188
VL - 10
JO - Therapeutic Advances in Endocrinology and Metabolism
JF - Therapeutic Advances in Endocrinology and Metabolism
ER -