TY - JOUR
T1 - The interplay of thyroid hormones and the immune system - where we stand and why we need to know about it
AU - Wenzek, Christina
AU - Boelen, Anita
AU - Westendorf, Astrid M.
AU - Engel, Daniel R.
AU - Moeller, Lars C.
AU - Fuhrer, Dagmar
N1 - Funding Information: This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation): Project-ID 424957847 – TRR 296; RTG 1949. Publisher Copyright: © 2022 BioScientifica Ltd.. All rights reserved.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Over the past few years, growing evidence suggests direct crosstalk between thyroid hormones (THs) and the immune system. Components of the immune system were proposed to interfere with the central regulation of systemic TH levels. Conversely, THs regulate innate and adaptive immune responses as immune cells are direct target cells of THs. Accordingly, they express different components of local TH action, such as TH transporters or receptors, but our picture of the interplay between THs and the immune system is still incomplete. This review provides a critical overview of current knowledge regarding the interaction of THs and the immune system with the main focus on local TH action within major innate and adaptive immune cell subsets. Thereby, this review aims to highlight open issues which might help to infer the clinical relevance of THs in host defence in the context of different types of diseases such as infection, ischemic organ injury or cancer.
AB - Over the past few years, growing evidence suggests direct crosstalk between thyroid hormones (THs) and the immune system. Components of the immune system were proposed to interfere with the central regulation of systemic TH levels. Conversely, THs regulate innate and adaptive immune responses as immune cells are direct target cells of THs. Accordingly, they express different components of local TH action, such as TH transporters or receptors, but our picture of the interplay between THs and the immune system is still incomplete. This review provides a critical overview of current knowledge regarding the interaction of THs and the immune system with the main focus on local TH action within major innate and adaptive immune cell subsets. Thereby, this review aims to highlight open issues which might help to infer the clinical relevance of THs in host defence in the context of different types of diseases such as infection, ischemic organ injury or cancer.
UR - http://www.scopus.com/inward/record.url?scp=85126289010&partnerID=8YFLogxK
U2 - https://doi.org/10.1530/EJE-21-1171
DO - https://doi.org/10.1530/EJE-21-1171
M3 - Review article
C2 - 35175936
SN - 0804-4643
VL - 168
SP - R65-R77
JO - European journal of endocrinology
JF - European journal of endocrinology
IS - 5
ER -