The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting

Josephine Mathilde Elisabeth Tan, Miesje Maxime van der Stoel, Marlene van den Berg, Nienke Marlies van Loon, Martina Moeton, Edwin Scholl, Nicole Neeltje van der Wel, Igor Kovačević, Peter Lodewijk Hordijk, Anke Loregger, Stephan Huveneers, Noam Zelcer

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8 Citations (Scopus)

Abstract

Tan et al. identify the E3-ligase MARCH6 as an important regulator of endothelial sprouting angiogenesis, owing to its ability to degrade the cholesterol biosynthetic enzyme SQLE. The study highlights that adequate SQLE levels are a critical determinant of maintaining endothelial junctions and proper sprouting angiogenesis.

Original languageEnglish
Article number107944
JournalCell Reports
Volume32
Issue number5
DOIs
Publication statusPublished - 4 Aug 2020

Keywords

  • MARCH6
  • MARCHF6
  • SQLE
  • VE-cadherin
  • adherens junction
  • angiogenesis
  • cholesterol metabolism
  • endothelial barrier
  • membrane organization
  • post-transcriptional regulation

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