Abstract
Tan et al. identify the E3-ligase MARCH6 as an important regulator of endothelial sprouting angiogenesis, owing to its ability to degrade the cholesterol biosynthetic enzyme SQLE. The study highlights that adequate SQLE levels are a critical determinant of maintaining endothelial junctions and proper sprouting angiogenesis.
Original language | English |
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Article number | 107944 |
Journal | Cell reports |
Volume | 32 |
Issue number | 5 |
DOIs | |
Publication status | Published - 4 Aug 2020 |
Keywords
- MARCH6
- MARCHF6
- SQLE
- VE-cadherin
- adherens junction
- angiogenesis
- cholesterol metabolism
- endothelial barrier
- membrane organization
- post-transcriptional regulation