Abstract
The minor histocompatibility antigen (mHag) HA-1 is the only known mHag for which mismatching is correlated with the development of severe graft versus host disease (GvHD) after human leukocyte antigen-identical bone marrow transplantation. HA-1 was found to be a nonapeptide derived from an allele of the KIAA0223 gene. The HA-1-negative allelic counterpart encoded by KIAA0223 had one amino acid difference from HA-1. Family analysis with HA-1 allele-specific polymerase chain reaction showed an exact correlation between this allelic polymorphism and the HA-1 phenotype. HA-1 allele typing of donor and recipient should improve donor selection and allow the determination of bone marrow transplantation recipients with high risk for HA-1-induced GvHD development.
| Original language | English |
|---|---|
| Pages (from-to) | 1054-7 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 279 |
| Issue number | 5353 |
| Publication status | Published - 13 Feb 1998 |
Keywords
- Alleles
- Amino Acid Sequence
- Bone Marrow Transplantation/adverse effects
- Cell Line
- Cell Line, Transformed
- Female
- Graft vs Host Disease/immunology
- HLA-A Antigens/immunology
- Histocompatibility Testing
- Humans
- Male
- Mass Spectrometry
- Minor Histocompatibility Antigens/chemistry
- Minor Histocompatibility Loci
- Oligopeptides/chemistry
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Genetic
- T-Lymphocytes, Cytotoxic/immunology