The mother-to-child HIV transmission epidemic in Europe: evolving in the East and established in the West

C. Giaquinto; O. Rampon; R. D'Elia; A. de Rossi; I. Grosch-Woerner; C. Feiterna-Sperling; T. Schmitz; S. Casteleyn; J. Mok; I. de Jose; I. Bates; B. Larru; J. M. Pena; J. Gonzalez Garcia; J. R. Arribas Lopez; M. C. Garcia-Rodriguez; F. Asensi-Botet; M. C. Otero; D. Perez-Tamarit; G. Suarez; H. Scherpbier; M. Kreyenbroek; M. H. Godfried; F. J. Nellen; K. Boer; A. B. Bohlin; S. Lindgren; E. Belfrage; L. Naver; B. Anzen; K. Lidman; J. Levy; M. Hainaut; T. Goetghebuer; Y. Manigart; P. Barlow; A. Ferrazin; D. Bassetti; A. de Maria; G. Bentivoglio; S. Ferrero; C. Gotta; A. Mur; A. Paya; M. A. Lopez-Vilchez; R. Carreras; N. H. Valerius; J. Jimenez; O. Coll; A. Suy; J. M. Perez; C. Fortuny; J. Boguna; M. Casellas Caro; Y. Canet; G. Pardi; M. Ravizza; B. Guerra; M. Lanari; S. Bianchi; L. Bovicelli; E. Prati; M. Duse; G. Scaravelli; M. Stegagno; M. de Santis; V. Savasi; E. Ferrazzi; A. Vigano; V. Giacomet; F. Ravagni Probizer; A. Maccabruni; A. Bucceri; L. Rancilio; S. Alberico; M. Rabusin; M. Bernardon; G. P. Taylor; E. G. H. Lyall; Z. Penn; W. Buffolano; R. Tiseo; P. Martinelli; M. Sansone; A. Agangi; C. Tibaldi; S. Marini; G. Masuelli; C. Benedetto; T. Niemiec; M. Marczynska; A. Oldakowska; M. Kaflik; S. Posokhova; T. Kaleeva; A. Stelmah; G. Kiseleva

The mother-to-child HIV transmission epidemic in Europe: evolving in the East and established in the West

C. Giaquinto, O. Rampon, R. D'Elia, A. de Rossi, I. Grosch-Woerner, C. Feiterna-Sperling, T. Schmitz, S. Casteleyn, J. Mok, I. de Jose, I. Bates, B. Larru, J. M. Pena, J. Gonzalez Garcia, J. R. Arribas Lopez, M. C. Garcia-Rodriguez, F. Asensi-Botet, M. C. Otero, D. Perez-Tamarit, G. SuarezH. Scherpbier, M. Kreyenbroek, M. H. Godfried, F. J. Nellen, K. Boer, A. B. Bohlin, S. Lindgren, E. Belfrage, L. Naver, B. Anzen, K. Lidman, J. Levy, M. Hainaut, T. Goetghebuer, Y. Manigart, P. Barlow, A. Ferrazin, D. Bassetti, A. de Maria, G. Bentivoglio, S. Ferrero, C. Gotta, A. Mur, A. Paya, M. A. Lopez-Vilchez, R. Carreras, N. H. Valerius, J. Jimenez, O. Coll, A. Suy, J. M. Perez, C. Fortuny, J. Boguna, M. Casellas Caro, Y. Canet, G. Pardi, M. Ravizza, B. Guerra, M. Lanari, S. Bianchi, L. Bovicelli, E. Prati, M. Duse, G. Scaravelli, M. Stegagno, M. de Santis, V. Savasi, E. Ferrazzi, A. Vigano, V. Giacomet, F. Ravagni Probizer, A. Maccabruni, A. Bucceri, L. Rancilio, S. Alberico, M. Rabusin, M. Bernardon, G. P. Taylor, E. G. H. Lyall, Z. Penn, W. Buffolano, R. Tiseo, P. Martinelli, M. Sansone, A. Agangi, C. Tibaldi, S. Marini, G. Masuelli, C. Benedetto, T. Niemiec, M. Marczynska, A. Oldakowska, M. Kaflik, S. Posokhova, T. Kaleeva, A. Stelmah, G. Kiseleva

Research output: Contribution to journal › Article › Academic › peer-review

54 Citations (Scopus)

Abstract

Objectives: To carry out an epidemiological analysis of the emerging epidemic in an Eastern European country and to compare the approach to prevention of mother-to-child transmission (MTCT) with that in Western Europe. Design: Prospective cohort study established in 1985 in Western Europe and extended to Ukraine in 2000. Methods: Data on 5967 HIV-infected pregnant women and their infants (1251 from Ukraine and 4716 from Western/Central Europe) was analysed. Factors associated with transmission were identified with logistic regression. Results: HIV-infection among pregnant women enrolled in Western European centres has shifted from being largely injecting drug use (IDU)-related to heterosexually-acquired; in Ukraine IDU also gradually declined with women increasingly identified without specific risk factors. In Ukraine in 2000-2004 most (80%) women received single dose nevirapine (sdNVP) and/or short-course zidovudine prophylaxis [MTCT rate 4.2%; 95% confidence interval (CI), 1.8-8.0 for sdNVP with short-course zidovudinel; 2% (n = 27) received antenatal HAART and 33% (n = 418) delivered by elective caesarean section (CS); in Western European centres 72% of women received HAART (MTCT rate 1.0%; 95% Cl, 0.4-1.9) and 66% delivered by elective CS during the same period. Conclusions: Our findings indicate distinct differences in the epidemics in pregnant women across Europe. The evolution of the MTCT epidemic in Ukraine does not appear to be following the same pattern as that in Western Europe in the 1980s and 1990s. Although uptake of preventive MTCT prophylaxis has been rapid in both Western Europe and Ukraine, substantial challenges remain in the more resource-constrained setting in Eastern Europe. (c) 2006 Lippincott Williams & Wilkins

Original language	English
Pages (from-to)	1419-1427
Journal	AIDS (London, England)
Volume	20
Issue number	10
Publication status	Published - 2006

Cite this

Giaquinto, C., Rampon, O., D'Elia, R., de Rossi, A., Grosch-Woerner, I., Feiterna-Sperling, C., Schmitz, T., Casteleyn, S., Mok, J., de Jose, I., Bates, I., Larru, B., Pena, J. M., Garcia, J. G., Lopez, J. R. A., Garcia-Rodriguez, M. C., Asensi-Botet, F., Otero, M. C., Perez-Tamarit, D., ... Kiseleva, G. (2006). The mother-to-child HIV transmission epidemic in Europe: evolving in the East and established in the West. AIDS (London, England), 20(10), 1419-1427.

@article{39f085bd45f24026aa96946446ab2983,

title = "The mother-to-child HIV transmission epidemic in Europe: evolving in the East and established in the West",

abstract = "Objectives: To carry out an epidemiological analysis of the emerging epidemic in an Eastern European country and to compare the approach to prevention of mother-to-child transmission (MTCT) with that in Western Europe. Design: Prospective cohort study established in 1985 in Western Europe and extended to Ukraine in 2000. Methods: Data on 5967 HIV-infected pregnant women and their infants (1251 from Ukraine and 4716 from Western/Central Europe) was analysed. Factors associated with transmission were identified with logistic regression. Results: HIV-infection among pregnant women enrolled in Western European centres has shifted from being largely injecting drug use (IDU)-related to heterosexually-acquired; in Ukraine IDU also gradually declined with women increasingly identified without specific risk factors. In Ukraine in 2000-2004 most (80%) women received single dose nevirapine (sdNVP) and/or short-course zidovudine prophylaxis [MTCT rate 4.2%; 95% confidence interval (CI), 1.8-8.0 for sdNVP with short-course zidovudinel; 2% (n = 27) received antenatal HAART and 33% (n = 418) delivered by elective caesarean section (CS); in Western European centres 72% of women received HAART (MTCT rate 1.0%; 95% Cl, 0.4-1.9) and 66% delivered by elective CS during the same period. Conclusions: Our findings indicate distinct differences in the epidemics in pregnant women across Europe. The evolution of the MTCT epidemic in Ukraine does not appear to be following the same pattern as that in Western Europe in the 1980s and 1990s. Although uptake of preventive MTCT prophylaxis has been rapid in both Western Europe and Ukraine, substantial challenges remain in the more resource-constrained setting in Eastern Europe. (c) 2006 Lippincott Williams & Wilkins",

author = "C. Giaquinto and O. Rampon and R. D'Elia and {de Rossi}, A. and I. Grosch-Woerner and C. Feiterna-Sperling and T. Schmitz and S. Casteleyn and J. Mok and {de Jose}, I. and I. Bates and B. Larru and Pena, {J. M.} and Garcia, {J. Gonzalez} and Lopez, {J. R. Arribas} and Garcia-Rodriguez, {M. C.} and F. Asensi-Botet and Otero, {M. C.} and D. Perez-Tamarit and G. Suarez and H. Scherpbier and M. Kreyenbroek and Godfried, {M. H.} and Nellen, {F. J.} and K. Boer and Bohlin, {A. B.} and S. Lindgren and E. Belfrage and L. Naver and B. Anzen and K. Lidman and J. Levy and M. Hainaut and T. Goetghebuer and Y. Manigart and P. Barlow and A. Ferrazin and D. Bassetti and {de Maria}, A. and G. Bentivoglio and S. Ferrero and C. Gotta and A. Mur and A. Paya and Lopez-Vilchez, {M. A.} and R. Carreras and Valerius, {N. H.} and J. Jimenez and O. Coll and A. Suy and Perez, {J. M.} and C. Fortuny and J. Boguna and Caro, {M. Casellas} and Y. Canet and G. Pardi and M. Ravizza and B. Guerra and M. Lanari and S. Bianchi and L. Bovicelli and E. Prati and M. Duse and G. Scaravelli and M. Stegagno and {de Santis}, M. and V. Savasi and E. Ferrazzi and A. Vigano and V. Giacomet and Probizer, {F. Ravagni} and A. Maccabruni and A. Bucceri and L. Rancilio and S. Alberico and M. Rabusin and M. Bernardon and Taylor, {G. P.} and Lyall, {E. G. H.} and Z. Penn and W. Buffolano and R. Tiseo and P. Martinelli and M. Sansone and A. Agangi and C. Tibaldi and S. Marini and G. Masuelli and C. Benedetto and T. Niemiec and M. Marczynska and A. Oldakowska and M. Kaflik and S. Posokhova and T. Kaleeva and A. Stelmah and G. Kiseleva",

year = "2006",

language = "English",

volume = "20",

pages = "1419--1427",

journal = "AIDS (London, England)",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "10",

}

Giaquinto, C, Rampon, O, D'Elia, R, de Rossi, A, Grosch-Woerner, I, Feiterna-Sperling, C, Schmitz, T, Casteleyn, S, Mok, J, de Jose, I, Bates, I, Larru, B, Pena, JM, Garcia, JG, Lopez, JRA, Garcia-Rodriguez, MC, Asensi-Botet, F, Otero, MC, Perez-Tamarit, D, Suarez, G, Scherpbier, H, Kreyenbroek, M, Godfried, MH, Nellen, FJ, Boer, K, Bohlin, AB, Lindgren, S, Belfrage, E, Naver, L, Anzen, B, Lidman, K, Levy, J, Hainaut, M, Goetghebuer, T, Manigart, Y, Barlow, P, Ferrazin, A, Bassetti, D, de Maria, A, Bentivoglio, G, Ferrero, S, Gotta, C, Mur, A, Paya, A, Lopez-Vilchez, MA, Carreras, R, Valerius, NH, Jimenez, J, Coll, O, Suy, A, Perez, JM, Fortuny, C, Boguna, J, Caro, MC, Canet, Y, Pardi, G, Ravizza, M, Guerra, B, Lanari, M, Bianchi, S, Bovicelli, L, Prati, E, Duse, M, Scaravelli, G, Stegagno, M, de Santis, M, Savasi, V, Ferrazzi, E, Vigano, A, Giacomet, V, Probizer, FR, Maccabruni, A, Bucceri, A, Rancilio, L, Alberico, S, Rabusin, M, Bernardon, M, Taylor, GP, Lyall, EGH, Penn, Z, Buffolano, W, Tiseo, R, Martinelli, P, Sansone, M, Agangi, A, Tibaldi, C, Marini, S, Masuelli, G, Benedetto, C, Niemiec, T, Marczynska, M, Oldakowska, A, Kaflik, M, Posokhova, S, Kaleeva, T, Stelmah, A & Kiseleva, G 2006, 'The mother-to-child HIV transmission epidemic in Europe: evolving in the East and established in the West', AIDS (London, England), vol. 20, no. 10, pp. 1419-1427.

TY - JOUR

T1 - The mother-to-child HIV transmission epidemic in Europe: evolving in the East and established in the West

AU - Giaquinto, C.

AU - Rampon, O.

AU - D'Elia, R.

AU - de Rossi, A.

AU - Grosch-Woerner, I.

AU - Feiterna-Sperling, C.

AU - Schmitz, T.

AU - Casteleyn, S.

AU - Mok, J.

AU - de Jose, I.

AU - Bates, I.

AU - Larru, B.

AU - Pena, J. M.

AU - Garcia, J. Gonzalez

AU - Lopez, J. R. Arribas

AU - Garcia-Rodriguez, M. C.

AU - Asensi-Botet, F.

AU - Otero, M. C.

AU - Perez-Tamarit, D.

AU - Suarez, G.

AU - Scherpbier, H.

AU - Kreyenbroek, M.

AU - Godfried, M. H.

AU - Nellen, F. J.

AU - Boer, K.

AU - Bohlin, A. B.

AU - Lindgren, S.

AU - Belfrage, E.

AU - Naver, L.

AU - Anzen, B.

AU - Lidman, K.

AU - Levy, J.

AU - Hainaut, M.

AU - Goetghebuer, T.

AU - Manigart, Y.

AU - Barlow, P.

AU - Ferrazin, A.

AU - Bassetti, D.

AU - de Maria, A.

AU - Bentivoglio, G.

AU - Ferrero, S.

AU - Gotta, C.

AU - Mur, A.

AU - Paya, A.

AU - Lopez-Vilchez, M. A.

AU - Carreras, R.

AU - Valerius, N. H.

AU - Jimenez, J.

AU - Coll, O.

AU - Suy, A.

AU - Perez, J. M.

AU - Fortuny, C.

AU - Boguna, J.

AU - Caro, M. Casellas

AU - Canet, Y.

AU - Pardi, G.

AU - Ravizza, M.

AU - Guerra, B.

AU - Lanari, M.

AU - Bianchi, S.

AU - Bovicelli, L.

AU - Prati, E.

AU - Duse, M.

AU - Scaravelli, G.

AU - Stegagno, M.

AU - de Santis, M.

AU - Savasi, V.

AU - Ferrazzi, E.

AU - Vigano, A.

AU - Giacomet, V.

AU - Probizer, F. Ravagni

AU - Maccabruni, A.

AU - Bucceri, A.

AU - Rancilio, L.

AU - Alberico, S.

AU - Rabusin, M.

AU - Bernardon, M.

AU - Taylor, G. P.

AU - Lyall, E. G. H.

AU - Penn, Z.

AU - Buffolano, W.

AU - Tiseo, R.

AU - Martinelli, P.

AU - Sansone, M.

AU - Agangi, A.

AU - Tibaldi, C.

AU - Marini, S.

AU - Masuelli, G.

AU - Benedetto, C.

AU - Niemiec, T.

AU - Marczynska, M.

AU - Oldakowska, A.

AU - Kaflik, M.

AU - Posokhova, S.

AU - Kaleeva, T.

AU - Stelmah, A.

AU - Kiseleva, G.

PY - 2006

Y1 - 2006

N2 - Objectives: To carry out an epidemiological analysis of the emerging epidemic in an Eastern European country and to compare the approach to prevention of mother-to-child transmission (MTCT) with that in Western Europe. Design: Prospective cohort study established in 1985 in Western Europe and extended to Ukraine in 2000. Methods: Data on 5967 HIV-infected pregnant women and their infants (1251 from Ukraine and 4716 from Western/Central Europe) was analysed. Factors associated with transmission were identified with logistic regression. Results: HIV-infection among pregnant women enrolled in Western European centres has shifted from being largely injecting drug use (IDU)-related to heterosexually-acquired; in Ukraine IDU also gradually declined with women increasingly identified without specific risk factors. In Ukraine in 2000-2004 most (80%) women received single dose nevirapine (sdNVP) and/or short-course zidovudine prophylaxis [MTCT rate 4.2%; 95% confidence interval (CI), 1.8-8.0 for sdNVP with short-course zidovudinel; 2% (n = 27) received antenatal HAART and 33% (n = 418) delivered by elective caesarean section (CS); in Western European centres 72% of women received HAART (MTCT rate 1.0%; 95% Cl, 0.4-1.9) and 66% delivered by elective CS during the same period. Conclusions: Our findings indicate distinct differences in the epidemics in pregnant women across Europe. The evolution of the MTCT epidemic in Ukraine does not appear to be following the same pattern as that in Western Europe in the 1980s and 1990s. Although uptake of preventive MTCT prophylaxis has been rapid in both Western Europe and Ukraine, substantial challenges remain in the more resource-constrained setting in Eastern Europe. (c) 2006 Lippincott Williams & Wilkins

AB - Objectives: To carry out an epidemiological analysis of the emerging epidemic in an Eastern European country and to compare the approach to prevention of mother-to-child transmission (MTCT) with that in Western Europe. Design: Prospective cohort study established in 1985 in Western Europe and extended to Ukraine in 2000. Methods: Data on 5967 HIV-infected pregnant women and their infants (1251 from Ukraine and 4716 from Western/Central Europe) was analysed. Factors associated with transmission were identified with logistic regression. Results: HIV-infection among pregnant women enrolled in Western European centres has shifted from being largely injecting drug use (IDU)-related to heterosexually-acquired; in Ukraine IDU also gradually declined with women increasingly identified without specific risk factors. In Ukraine in 2000-2004 most (80%) women received single dose nevirapine (sdNVP) and/or short-course zidovudine prophylaxis [MTCT rate 4.2%; 95% confidence interval (CI), 1.8-8.0 for sdNVP with short-course zidovudinel; 2% (n = 27) received antenatal HAART and 33% (n = 418) delivered by elective caesarean section (CS); in Western European centres 72% of women received HAART (MTCT rate 1.0%; 95% Cl, 0.4-1.9) and 66% delivered by elective CS during the same period. Conclusions: Our findings indicate distinct differences in the epidemics in pregnant women across Europe. The evolution of the MTCT epidemic in Ukraine does not appear to be following the same pattern as that in Western Europe in the 1980s and 1990s. Although uptake of preventive MTCT prophylaxis has been rapid in both Western Europe and Ukraine, substantial challenges remain in the more resource-constrained setting in Eastern Europe. (c) 2006 Lippincott Williams & Wilkins

M3 - Article

SN - 0269-9370

VL - 20

SP - 1419

EP - 1427

JO - AIDS (London, England)

JF - AIDS (London, England)

IS - 10

ER -