The Mycobacterium leprae antigen 85 complex gene family: identification of the genes for the 85A, 85C, and related MPT51 proteins

T. F. Rinke de Wit, S. Bekelie, A. Osland, B. Wieles, A. A. Janson, J. E. Thole

Research output: Contribution to JournalArticleAcademicpeer-review

38 Citations (Scopus)

Abstract

The genes for two novel members (designated 85A and 85C) of the Mycobacterium leprae antigen 85 complex family of proteins and the gene for the closely related M. leprae MPT51 protein were isolated. The complete DNA sequence of the M. leprae 85C gene and partial sequences of the 85A and MPT51 genes are presented. As in M. tuberculosis, the M. leprae 85A, 85C, and previously identified 85B component genes are not closely linked on the genome. However, the MPT51 genes of both species localize close to the respective 85A component genes. Like the 85B component, the M. leprae 85A-MPT51 and 85C antigens are recognized by T cells from healthy contacts and leprosy patients
Original languageEnglish
Pages (from-to)3642-3647
JournalInfection and immunity
Volume61
Issue number9
Publication statusPublished - 1993

Cite this