The Mycobacterium leprae antigen 85 complex gene family: identification of the genes for the 85A, 85C, and related MPT51 proteins

T. F. Rinke de Wit; S. Bekelie; A. Osland; B. Wieles; A. A. Janson; J. E. Thole

The Mycobacterium leprae antigen 85 complex gene family: identification of the genes for the 85A, 85C, and related MPT51 proteins

T. F. Rinke de Wit, S. Bekelie, A. Osland, B. Wieles, A. A. Janson, J. E. Thole

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Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The genes for two novel members (designated 85A and 85C) of the Mycobacterium leprae antigen 85 complex family of proteins and the gene for the closely related M. leprae MPT51 protein were isolated. The complete DNA sequence of the M. leprae 85C gene and partial sequences of the 85A and MPT51 genes are presented. As in M. tuberculosis, the M. leprae 85A, 85C, and previously identified 85B component genes are not closely linked on the genome. However, the MPT51 genes of both species localize close to the respective 85A component genes. Like the 85B component, the M. leprae 85A-MPT51 and 85C antigens are recognized by T cells from healthy contacts and leprosy patients

Original language	English
Pages (from-to)	3642-3647
Journal	Infection and immunity
Volume	61
Issue number	9
Publication status	Published - 1993

Cite this

@article{75bef2316fc64c3cab7c48b456db1ad4,

title = "The Mycobacterium leprae antigen 85 complex gene family: identification of the genes for the 85A, 85C, and related MPT51 proteins",

abstract = "The genes for two novel members (designated 85A and 85C) of the Mycobacterium leprae antigen 85 complex family of proteins and the gene for the closely related M. leprae MPT51 protein were isolated. The complete DNA sequence of the M. leprae 85C gene and partial sequences of the 85A and MPT51 genes are presented. As in M. tuberculosis, the M. leprae 85A, 85C, and previously identified 85B component genes are not closely linked on the genome. However, the MPT51 genes of both species localize close to the respective 85A component genes. Like the 85B component, the M. leprae 85A-MPT51 and 85C antigens are recognized by T cells from healthy contacts and leprosy patients",

author = "{Rinke de Wit}, {T. F.} and S. Bekelie and A. Osland and B. Wieles and Janson, {A. A.} and Thole, {J. E.}",

year = "1993",

language = "English",

volume = "61",

pages = "3642--3647",

journal = "Infection and immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "9",

}

TY - JOUR

T1 - The Mycobacterium leprae antigen 85 complex gene family: identification of the genes for the 85A, 85C, and related MPT51 proteins

AU - Rinke de Wit, T. F.

AU - Bekelie, S.

AU - Osland, A.

AU - Wieles, B.

AU - Janson, A. A.

AU - Thole, J. E.

PY - 1993

Y1 - 1993

N2 - The genes for two novel members (designated 85A and 85C) of the Mycobacterium leprae antigen 85 complex family of proteins and the gene for the closely related M. leprae MPT51 protein were isolated. The complete DNA sequence of the M. leprae 85C gene and partial sequences of the 85A and MPT51 genes are presented. As in M. tuberculosis, the M. leprae 85A, 85C, and previously identified 85B component genes are not closely linked on the genome. However, the MPT51 genes of both species localize close to the respective 85A component genes. Like the 85B component, the M. leprae 85A-MPT51 and 85C antigens are recognized by T cells from healthy contacts and leprosy patients

AB - The genes for two novel members (designated 85A and 85C) of the Mycobacterium leprae antigen 85 complex family of proteins and the gene for the closely related M. leprae MPT51 protein were isolated. The complete DNA sequence of the M. leprae 85C gene and partial sequences of the 85A and MPT51 genes are presented. As in M. tuberculosis, the M. leprae 85A, 85C, and previously identified 85B component genes are not closely linked on the genome. However, the MPT51 genes of both species localize close to the respective 85A component genes. Like the 85B component, the M. leprae 85A-MPT51 and 85C antigens are recognized by T cells from healthy contacts and leprosy patients

M3 - Article

C2 - 8359887

SN - 0019-9567

VL - 61

SP - 3642

EP - 3647

JO - Infection and immunity

JF - Infection and immunity

IS - 9

ER -