The plasma concentration of soluble Fc-gamma RIII is related to production of neutrophils

T. W. Huizinga; M. de Haas; M. H. van Oers; M. Kleijer; H. Vilé; P. A. van der Wouw; A. Moulijn; H. van Weezel; D. Roos; A. E. von dem Borne

doi:https://doi.org/10.1111/j.1365-2141.1994.tb08298.x

The plasma concentration of soluble Fc-gamma RIII is related to production of neutrophils

T. W. Huizinga, M. de Haas, M. H. van Oers, M. Kleijer, H. Vilé, P. A. van der Wouw, A. Moulijn, H. van Weezel, D. Roos, A. E. von dem Borne

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Abstract

Fc gamma RIII (the CD16-antigen), a low-affinity receptor for IgG, is expressed by neutrophils, natural killer lymphocytes and macrophages. A soluble form of Fc gamma RIII has been identified in human plasma. This soluble form of Fc gamma RIII (sFc gamma RIII) originates from release by neutrophils. In the present study we show by transfusions of plasma that contains sFc gamma RIII of one allotype (NA1-Fc gamma RIII) in recipients homozygous for the other allotype (NA2-Fc gamma RIII) that the clearance of sFc gamma RIII is about 0.7 ml/min. Because the concentration of sFc gamma RIII was found to be constant in a small cohort of donors followed for about 1.5 years, the half-life of NA1-sFc gamma RIII is about 1.8 d, assuming a one-compartment model. The plasma concentration of sFc gamma RIII depended mainly on the production of neutrophils in the bone marrow, and was not influenced by shifts of neutrophils from one pool to another (storage, marginating or circulating pool). Because Fc gamma RIII is only expressed on mature neutrophils, this implies that the concentration of sFc gamma RIII depends on production of mature neutrophils

Original language	English
Pages (from-to)	459-463
Journal	British journal of haematology
Volume	87
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2141.1994.tb08298.x
Publication status	Published - 1994

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https://doi.org/10.1111/j.1365-2141.1994.tb08298.x

Cite this

@article{01a5cc84bad447648e3bae78838b9a5c,

title = "The plasma concentration of soluble Fc-gamma RIII is related to production of neutrophils",

abstract = "Fc gamma RIII (the CD16-antigen), a low-affinity receptor for IgG, is expressed by neutrophils, natural killer lymphocytes and macrophages. A soluble form of Fc gamma RIII has been identified in human plasma. This soluble form of Fc gamma RIII (sFc gamma RIII) originates from release by neutrophils. In the present study we show by transfusions of plasma that contains sFc gamma RIII of one allotype (NA1-Fc gamma RIII) in recipients homozygous for the other allotype (NA2-Fc gamma RIII) that the clearance of sFc gamma RIII is about 0.7 ml/min. Because the concentration of sFc gamma RIII was found to be constant in a small cohort of donors followed for about 1.5 years, the half-life of NA1-sFc gamma RIII is about 1.8 d, assuming a one-compartment model. The plasma concentration of sFc gamma RIII depended mainly on the production of neutrophils in the bone marrow, and was not influenced by shifts of neutrophils from one pool to another (storage, marginating or circulating pool). Because Fc gamma RIII is only expressed on mature neutrophils, this implies that the concentration of sFc gamma RIII depends on production of mature neutrophils",

author = "Huizinga, {T. W.} and {de Haas}, M. and {van Oers}, {M. H.} and M. Kleijer and H. Vil{\'e} and {van der Wouw}, {P. A.} and A. Moulijn and {van Weezel}, H. and D. Roos and {von dem Borne}, {A. E.}",

year = "1994",

doi = "https://doi.org/10.1111/j.1365-2141.1994.tb08298.x",

language = "English",

volume = "87",

pages = "459--463",

journal = "British journal of haematology",

issn = "0007-1048",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - The plasma concentration of soluble Fc-gamma RIII is related to production of neutrophils

AU - Huizinga, T. W.

AU - de Haas, M.

AU - van Oers, M. H.

AU - Kleijer, M.

AU - Vilé, H.

AU - van der Wouw, P. A.

AU - Moulijn, A.

AU - van Weezel, H.

AU - Roos, D.

AU - von dem Borne, A. E.

PY - 1994

Y1 - 1994

N2 - Fc gamma RIII (the CD16-antigen), a low-affinity receptor for IgG, is expressed by neutrophils, natural killer lymphocytes and macrophages. A soluble form of Fc gamma RIII has been identified in human plasma. This soluble form of Fc gamma RIII (sFc gamma RIII) originates from release by neutrophils. In the present study we show by transfusions of plasma that contains sFc gamma RIII of one allotype (NA1-Fc gamma RIII) in recipients homozygous for the other allotype (NA2-Fc gamma RIII) that the clearance of sFc gamma RIII is about 0.7 ml/min. Because the concentration of sFc gamma RIII was found to be constant in a small cohort of donors followed for about 1.5 years, the half-life of NA1-sFc gamma RIII is about 1.8 d, assuming a one-compartment model. The plasma concentration of sFc gamma RIII depended mainly on the production of neutrophils in the bone marrow, and was not influenced by shifts of neutrophils from one pool to another (storage, marginating or circulating pool). Because Fc gamma RIII is only expressed on mature neutrophils, this implies that the concentration of sFc gamma RIII depends on production of mature neutrophils

AB - Fc gamma RIII (the CD16-antigen), a low-affinity receptor for IgG, is expressed by neutrophils, natural killer lymphocytes and macrophages. A soluble form of Fc gamma RIII has been identified in human plasma. This soluble form of Fc gamma RIII (sFc gamma RIII) originates from release by neutrophils. In the present study we show by transfusions of plasma that contains sFc gamma RIII of one allotype (NA1-Fc gamma RIII) in recipients homozygous for the other allotype (NA2-Fc gamma RIII) that the clearance of sFc gamma RIII is about 0.7 ml/min. Because the concentration of sFc gamma RIII was found to be constant in a small cohort of donors followed for about 1.5 years, the half-life of NA1-sFc gamma RIII is about 1.8 d, assuming a one-compartment model. The plasma concentration of sFc gamma RIII depended mainly on the production of neutrophils in the bone marrow, and was not influenced by shifts of neutrophils from one pool to another (storage, marginating or circulating pool). Because Fc gamma RIII is only expressed on mature neutrophils, this implies that the concentration of sFc gamma RIII depends on production of mature neutrophils

U2 - https://doi.org/10.1111/j.1365-2141.1994.tb08298.x

DO - https://doi.org/10.1111/j.1365-2141.1994.tb08298.x

M3 - Article

C2 - 7527644

SN - 0007-1048

VL - 87

SP - 459

EP - 463

JO - British journal of haematology

JF - British journal of haematology

IS - 3

ER -