TY - JOUR
T1 - The potential of engineered antibodies for HIV-1 therapy and cure
AU - Grobben, Marloes
AU - Stuart, Richard A. L.
AU - van Gils, Marit J.
PY - 2019
Y1 - 2019
N2 - Broadly neutralizing antibodies (bnAbs) are currently under investigation as a therapy for HIV-1 infection and recent clinical trials have shown prolonged viral suppression by bnAbs during antiretroviral treatment interruption. Interestingly, these bnAbs also showed the ability to activate the host immune system to clear HIV-1 infected cells. There are many possibilities to further increase the potential efficacy of bnAbs. Most notably, Fc domain engineering to improve half-life and increase engagement of effector cells will augment two advantages of bnAbs. Moreover, antibody engineering can improve affinity and recognition of conserved epitopes and allows the combination of multiple epitope specificities in a single molecule. These increasingly potent and broad antibodies may prove valuable as alternative HIV-1 therapeutic and possibly in curative approaches.
AB - Broadly neutralizing antibodies (bnAbs) are currently under investigation as a therapy for HIV-1 infection and recent clinical trials have shown prolonged viral suppression by bnAbs during antiretroviral treatment interruption. Interestingly, these bnAbs also showed the ability to activate the host immune system to clear HIV-1 infected cells. There are many possibilities to further increase the potential efficacy of bnAbs. Most notably, Fc domain engineering to improve half-life and increase engagement of effector cells will augment two advantages of bnAbs. Moreover, antibody engineering can improve affinity and recognition of conserved epitopes and allows the combination of multiple epitope specificities in a single molecule. These increasingly potent and broad antibodies may prove valuable as alternative HIV-1 therapeutic and possibly in curative approaches.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85070490027&origin=inward
U2 - https://doi.org/10.1016/j.coviro.2019.07.007
DO - https://doi.org/10.1016/j.coviro.2019.07.007
M3 - Review article
C2 - 31421319
SN - 1879-6257
VL - 38
SP - 70
EP - 80
JO - Current opinion in virology
JF - Current opinion in virology
ER -