TY - JOUR
T1 - The Puzzle of Functional Recovery in Schizophrenia-Spectrum Disorders-Replicating a Network Analysis Study
AU - Moura, Bernardo Melo
AU - Isvoranu, Adela-Maria
AU - Kovacs, Veronika
AU - van Rooijen, Geeske
AU - van Amelsvoort, Therese
AU - Simons, Claudia J. P.
AU - Bartels-Velthuis, Agna A.
AU - Bakker, P. Roberto
AU - Marcelis, Machteld
AU - de Haan, Lieuwe
AU - Schirmbeck, Frederike
N1 - Funding Information: This work was supported by Fundacao para a Ciencia e Tecnologia (BMM, grant number PD/BD/128404/2017) and the James S. McDonnell Foundation Fellowship (AMI). Publisher Copyright: © 2022 The Author(s) 2022. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - BACKGROUND AND HYPOTHESIS: Recovery from psychosis is a complex phenomenon determined by an array of variables mutually impacting each other in a manner that is not fully understood. The aim of this study is to perform an approximated replication of a previous network analysis study investigating how different clinical aspects-covering psychopathology, cognition, personal resources, functional capacity, and real-life functioning-are interrelated in the context of schizophrenia-spectrum disorders. STUDY DESIGN: A sample of 843 subjects from a multisite cohort study, with the diagnosis of a schizophrenia-spectrum disorder, was used to estimate a network comprising 27 variables. The connectivity and relative importance of the variables was examined through network analysis. We used a quantitative and qualitative approach to infer replication quality. STUDY RESULTS: Functional capacity and real-life functioning were central and bridged different domains of the network, in line with the replicated study. Neurocognition, interpersonal relationships, and avolition were also key elements of the network, in close relation to aspects of functioning. Despite significant methodological differences, the current study could substantially replicate previous findings. CONCLUSIONS: Results solidify the network analysis approach in the context of mental disorders and further inform future studies about key variables in the context of recovery from psychotic disorders.
AB - BACKGROUND AND HYPOTHESIS: Recovery from psychosis is a complex phenomenon determined by an array of variables mutually impacting each other in a manner that is not fully understood. The aim of this study is to perform an approximated replication of a previous network analysis study investigating how different clinical aspects-covering psychopathology, cognition, personal resources, functional capacity, and real-life functioning-are interrelated in the context of schizophrenia-spectrum disorders. STUDY DESIGN: A sample of 843 subjects from a multisite cohort study, with the diagnosis of a schizophrenia-spectrum disorder, was used to estimate a network comprising 27 variables. The connectivity and relative importance of the variables was examined through network analysis. We used a quantitative and qualitative approach to infer replication quality. STUDY RESULTS: Functional capacity and real-life functioning were central and bridged different domains of the network, in line with the replicated study. Neurocognition, interpersonal relationships, and avolition were also key elements of the network, in close relation to aspects of functioning. Despite significant methodological differences, the current study could substantially replicate previous findings. CONCLUSIONS: Results solidify the network analysis approach in the context of mental disorders and further inform future studies about key variables in the context of recovery from psychotic disorders.
KW - cognition
KW - functional capacity
KW - functioning
KW - psychopathology
KW - psychosis
KW - resilience
UR - http://www.scopus.com/inward/record.url?scp=85132455914&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/schbul/sbac018
DO - https://doi.org/10.1093/schbul/sbac018
M3 - Article
C2 - 35266000
SN - 0586-7614
VL - 48
SP - 871
EP - 880
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - 4
ER -