The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators

Claudia M. Persoon, Rein I. Hoogstraaten, Joris P. Nassal, Jan R.T. van Weering, Pascal S. Kaeser, Ruud F. Toonen, Matthijs Verhage

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Abstract

Neurons secrete neuromodulators/neuropeptides from dense-core vesicles (DCVs) by a largely unknown mechanism. Persoon et al. identify RAB3 and RIM1/2 as essential factors. RAB3’s indispensable role is the first distinct feature of DCV secretion as compared to synaptic vesicle secretion.

Original languageEnglish
Pages (from-to)1065-1080.e12
Number of pages29
JournalNeuron
Volume104
Issue number6
Early online date31 Oct 2019
DOIs
Publication statusPublished - 18 Dec 2019

Keywords

  • BDNF
  • MUNC13
  • NPY
  • RAB3
  • RIM1/2
  • SEC4
  • dense-core vesicles
  • neuromodulators
  • neuropeptide
  • secretion

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