Abstract
Neurons secrete neuromodulators/neuropeptides from dense-core vesicles (DCVs) by a largely unknown mechanism. Persoon et al. identify RAB3 and RIM1/2 as essential factors. RAB3’s indispensable role is the first distinct feature of DCV secretion as compared to synaptic vesicle secretion.
Original language | English |
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Pages (from-to) | 1065-1080.e12 |
Number of pages | 29 |
Journal | Neuron |
Volume | 104 |
Issue number | 6 |
Early online date | 31 Oct 2019 |
DOIs | |
Publication status | Published - 18 Dec 2019 |
Keywords
- BDNF
- MUNC13
- NPY
- RAB3
- RIM1/2
- SEC4
- dense-core vesicles
- neuromodulators
- neuropeptide
- secretion