The relation between insulin-like growth factor I levels and cognition in healthy elderly: a meta-analysis: a meta-analysis

L.I. Arwert, J.B. Deijen, M.L. Drent

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80 Citations (Scopus)


Objective: Insulin-like growth factor I (IGF-I) levels and cognitive functioning decrease with aging. Several studies report positive correlations between IGF-I levels and cognitive functioning in healthy elderly. However, because of controversial data no definitive conclusions can be drawn concerning the relation between IGF-I and cognition. Therefore, we carried out a meta-analysis on studies that report on the relation between IGF-I and cognition in healthy elderly. Design: We searched the electronic databases for articles about IGF-I and cognition. Studies from 1985 to January 2005 are included. Two reviewers independently extracted data on study design and cognitive outcomes. Thirteen studies on IGF-I and cognition in elderly, with a total number of 1981 subjects, met the inclusion criteria. On the data from these studies meta-analyses were carried out by means of the program Comprehensive Meta-analysis using a random effects model. Results: Pooled effects show that IGF-I levels in healthy elderly have a positive correlation with cognitive functioning, which appeared to be mainly measured with the mini mental state examination (MMSE). The effect size is 0.6, which indicates the presence of a large positive relationship between IGF and cognition in healthy elderly. Conclusion: These meta-analyses showed an overall relationship between IGF-I levels and cognitive functioning in healthy elderly. Further studies should be performed to clarify the role of IGF-I substitution in preserving cognitive functions with aging. © 2005 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)416-422
Number of pages7
JournalGrowth Hormone and IGF Research
Issue number6
Publication statusPublished - Dec 2005


  • Aged
  • Aged, 80 and over
  • Aging
  • Attention
  • Cognition
  • Cognition Disorders
  • Female
  • Growth Hormone
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3/blood
  • Insulin-Like Growth Factor Binding Proteins/metabolism
  • Insulin-Like Growth Factor I/biosynthesis
  • Male
  • Memory
  • Memory Disorders
  • Mental Status Schedule
  • Middle Aged
  • Neuropsychological Tests
  • Surveys and Questionnaires

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