The relationship between the severity of oral dryness and the use of dry-mouth interventions by various subgroups of dry-mouth patients

Z. Assy, H. S. Brand, C. P. Bots, F. J. Bikker

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)


Objective: Dry-mouth patients use different interventions to relieve their oral dryness. As recent studies showed that various subgroups of dry-mouth patients perceived different intra-oral regions as most dry, the present study investigated whether the use of dry-mouth interventions by various subgroups of dry-mouth patients was related to the perceived oral dryness as well as salivary flow rate. Materials and methods: Xerostomia Inventory (XI) scores, Regional Oral Dryness Score (RODI) scores and used dry-mouth interventions were extracted from the medical records of 528 patients visiting a saliva clinic. Based on their medical history, they were allocated into 6 subgroups. Results: The subgroups of dry-mouth patients used a wide range of interventions to relieve their oral dryness. Sjögren’s syndrome patients used most interventions more frequently than patients with oral dryness due to use of a limited number of medications and controls. Patients using medications showed associations between the total XI score and dry-mouth interventions aimed at the entire mouth. In medication using patients and controls, the locally applied intervention “using mouth gel” was associated with RODI scores of the anterior tongue. Conclusion: The use of dry-mouth interventions was associated with dry-mouth feelings. Use of interventions aimed to relieve dryness of the entire mouth was significantly associated with total XI score, while locally applied interventions were significantly associated with the severity of dryness at specific intra-oral regions, the anterior tongue in particular. Clinical relevance: The results will help clinicians to advise dry-mouth patients about the most suitable interventions for relief of oral dryness complaints.
Original languageEnglish
Pages (from-to)3097-3108
Number of pages12
JournalClinical Oral Investigations
Issue number3
Early online date10 Jan 2022
Publication statusPublished - 1 Mar 2022


  • Dry-mouth
  • Dry-mouth interventions
  • Salivary flow rate
  • Sjögren’s syndrome
  • Xerostomia
  • Xerostomia Inventory

Cite this