The role of CD45+CD4+CD3- cells in lymphoid organ development

Tom Cupedo, Georg Kraal, Reina E Mebius

Research output: Contribution to journalReview articleAcademicpeer-review

69 Citations (Scopus)


In the last 10 years the continuing search for gene function has yielded many mutant mice that unexpectedly showed a complete lack of lymph nodes and/or Peyer's patches. With the realization that all these functionally highly diverse genes are involved at some point in the development of lymphoid organs, the challenge now is to assign a function to the molecules involved in lymphoid organ development. It will be important to determine the sequence of molecular events and assign this to the cellular events that lead to an accumulation of hematopoietic cells in one location, ultimately forming an organized lymphoid organ. Here we will focus on CD45+CD4+CD3- cells that are the early colonizing cells in lymph nodes and Peyer's patches and develop a hypothetical model of their contribution to the creation of organized lymphoid structures.

Original languageEnglish
Pages (from-to)41-50
Number of pages10
JournalImmunological reviews
Publication statusPublished - Nov 2002


  • Animals
  • CD3 Complex/metabolism
  • CD4-Positive T-Lymphocytes/cytology
  • Carrier Proteins/immunology
  • Fetus/cytology
  • Gene Expression Regulation, Developmental
  • Humans
  • Leukocyte Common Antigens/metabolism
  • Liver/cytology
  • Lymph Nodes/cytology
  • Lymphatic System/cytology
  • Membrane Glycoproteins/immunology
  • Mice
  • Mice, Mutant Strains
  • Models, Immunological
  • Peyer's Patches/cytology
  • RANK Ligand
  • Receptor Activator of Nuclear Factor-kappa B
  • T-Lymphocyte Subsets/cytology

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