TY - JOUR
T1 - The role of melanocortins and Neuropeptide Y in food reward
AU - Pandit, R.
AU - La Fleur, S. E.
AU - Adan, R. A. H.
PY - 2013
Y1 - 2013
N2 - The Neuropeptide Y and the melanocortin peptides are two well-described hypothalamic feeding peptides regulating energy balance. Predominantly expressed within the arcuate nucleus, these neurons project to different brain areas and modulate various aspects of feeding. Hedonic feeding, where one overindulges in palatable food consumption beyond one's nutritional necessities, is one such aspect regulated by NPY/melanocortin signaling. Research suggests that NPY/melanocortin regulate hedonic aspects of feeding through its projections to the brain reward circuitry (ventral tegmental area, lateral hypothalamus, nucleus accumbens etc.), however, exact target areas have not yet been identified. The current work explores literature to provide a mechanistic explanation for the effects of these peptides on food reward
AB - The Neuropeptide Y and the melanocortin peptides are two well-described hypothalamic feeding peptides regulating energy balance. Predominantly expressed within the arcuate nucleus, these neurons project to different brain areas and modulate various aspects of feeding. Hedonic feeding, where one overindulges in palatable food consumption beyond one's nutritional necessities, is one such aspect regulated by NPY/melanocortin signaling. Research suggests that NPY/melanocortin regulate hedonic aspects of feeding through its projections to the brain reward circuitry (ventral tegmental area, lateral hypothalamus, nucleus accumbens etc.), however, exact target areas have not yet been identified. The current work explores literature to provide a mechanistic explanation for the effects of these peptides on food reward
U2 - https://doi.org/10.1016/j.ejphar.2013.04.059
DO - https://doi.org/10.1016/j.ejphar.2013.04.059
M3 - Review article
C2 - 23872406
SN - 0014-2999
VL - 719
SP - 208
EP - 214
JO - European journal of pharmacology
JF - European journal of pharmacology
IS - 1-3
ER -