The role of microRNAs in skeletal muscle health and disease

Tyler J Kirby, Thomas Chaillou, John J McCarthy

Research output: Contribution to journalReview articleAcademicpeer-review

56 Citations (Scopus)


Over the last decade non-coding RNAs have emerged as importance regulators of gene expression. In particular, microRNAs are a class of small RNAs of ∼ 22 nucleotides that repress gene expression through a post-transcriptional mechanism. MicroRNAs have been shown to be involved in a broader range of biological processes, both physiological and pathological, including myogenesis, adaptation to exercise and various myopathies. The purpose of this review is to provide a comprehensive summary of what is currently known about the role of microRNAs in skeletal muscle health and disease.

Original languageEnglish
Pages (from-to)37-77
Number of pages41
JournalFrontiers in bioscience (Landmark edition)
Publication statusPublished - 1 Jan 2015


  • Humans
  • MicroRNAs/physiology
  • Muscle Development/physiology
  • Muscle, Skeletal/physiology
  • Muscular Atrophy/physiopathology
  • Muscular Diseases/physiopathology

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