TY - JOUR
T1 - The role of succinate in the regulation of intestinal inflammation
AU - Connors, Jessica
AU - Dawe, Nick
AU - van Limbergen, Johan
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported in association with microbiome disturbances (dysbiosis), as well as in patients with inflammatory bowel disease (IBD) and animal models of intestinal inflammation. Recent studies indicate that succinate can activate immune cells via its specific surface receptor, succinate receptor 1(SUCNR1), and enhance inflammation. However, the role of succinate in inflammatory processes within the gut mucosal immune system is unclear. This review includes current literature on the association of succinate with intestinal inflammation and the potential role of succinate–SUCNR1 signaling in gut immune functions.
AB - Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported in association with microbiome disturbances (dysbiosis), as well as in patients with inflammatory bowel disease (IBD) and animal models of intestinal inflammation. Recent studies indicate that succinate can activate immune cells via its specific surface receptor, succinate receptor 1(SUCNR1), and enhance inflammation. However, the role of succinate in inflammatory processes within the gut mucosal immune system is unclear. This review includes current literature on the association of succinate with intestinal inflammation and the potential role of succinate–SUCNR1 signaling in gut immune functions.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058910008&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30583500
U2 - https://doi.org/10.3390/nu11010025
DO - https://doi.org/10.3390/nu11010025
M3 - Review article
C2 - 30583500
SN - 2072-6643
VL - 11
JO - NUTRIENTS
JF - NUTRIENTS
IS - 1
M1 - 25
ER -