The role of tissue adhesives in esophageal surgery, a systematic review of literature

Victor Dirk Plat, Boukje Titia Bootsma, Nicole van der Wielen, Jennifer Straatman, Linda Jeanne Schoonmade, Donald Leonard van der Peet, Freek Daams

Research output: Contribution to journalReview articleAcademicpeer-review

19 Citations (Scopus)


Background Anastomotic leakage following esophageal surgery is a major contributor to mortality. According to the national database leakage occurs in 20% of esophagectomies carried out in the Netherlands. Therefore anastomotic leakage has been the topic of many studies. However, studies discussing application of tissue adhesives for either prevention or management of anastomotic leakage are limited. This article systematically reviewed all available literature on the potential use of tissue adhesives in esophageal surgery. Methods Medline, Embase and Cochrane were searched to identify studies that used tissue adhesives as anastomotic sealants to prevent esophageal anastomotic leakage or used tissue adhesives to treat esophageal anastomotic leakage. Two authors independently selected nineteen out of 3107 articles. Results Eight articles, of which five were experimental and three clinical, discussed prevention of anastomotic leakage. Eleven articles, of which one was experimental and ten clinical, discussed treatment of anastomotic leakage. Most articles reported positive results, however overall quality was low due to a high degree of bias and lack of homogeneity. Conclusion This study shows mainly positive results for the use of tissue adhesives for the esophageal anastomosis both in prevention of leakage as treating anastomotic leakage. However, the quality of current literature is poor.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalInternational Journal of Surgery
Publication statusPublished - 1 Apr 2017


  • Anastomotic leakage
  • Endoscopic treatment
  • Esophageal fistula
  • Fibrin sealant
  • Tissue adhesives
  • Upper GI surgery

Cite this