The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies

A J van Ballegooijen, J W Beulens

Research output: Contribution to journalReview articleAcademicpeer-review

53 Citations (Scopus)


PURPOSE OF REVIEW: Vitamin K is a fat-soluble vitamin required for the activation of several vitamin K-dependent proteins to confer functioning. A growing body of evidence supports that vitamin K has beneficial effects on bone and cardiovascular health. This review summarizes key evidence on vitamin K status as measured by circulating measures and cardiovascular outcomes.

RECENT FINDINGS: Overall, observational studies indicate that low vitamin K status as measured by high dephosphorylated uncarboxylated matrix gla protein concentrations plays a potential role in cardiovascular disease development, particularly in high-risk and chronic kidney disease populations. Very few vitamin K intervention trials have been conducted with cardiovascular-related outcomes. A couple of intervention trials studied the effect of the combination of vitamin D + K supplementation, which might have synergistic effects compared to vitamin K supplementation alone.

SUMMARY: Assessing vitamin K status in prospective studies and well-designed randomized trials would provide important insight whether vitamin K is causally related to vascular calcification and cardiovascular disease.

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalCurrent nutrition reports
Issue number3
Publication statusPublished - 2017


  • Journal Article
  • Review

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