The second human βB2-crystallin gene is a pseudogene

R. H. Brakenhoff, H. J.M. Aarts, F. Schuren, N. H. Lubsen, J. G.G. Schoenmakers

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Abstract

Comparison of the partial sequences of the human βB2-1- and βB2-2-crystallin genes with orthologous rat or calf sequences shows that the fourth exon sequence of the human βB2-2 gene contains a one triplet deletion and a mutated splice acceptor site. No transcripts from the βB2-2-crystallin gene could be detected in the human lens. These data suggest that the human βB2-2-crystallin gene is a pseudogene.

Original languageEnglish
Pages (from-to)803-806
Number of pages4
JournalExperimental eye research
Volume54
Issue number5
DOIs
Publication statusPublished - May 1992

Keywords

  • lens/splice site mutation

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