The SNARE protein vti1a functions in dense-core vesicle biogenesis

A.M. Walter, J. Kurps, H. de Wit, S. Schöning, R.L. Toft-Bertelsen, J. Lauks, I. Ziomkiewicz, A.N. Weiss, A. Schulz, G. Fischer von Mollard, M. Verhage, J.B. Sørensen

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Abstract

The SNARE protein vti1a is proposed to drive fusion of intracellular organelles, but recent data also implicated vti1a in exocytosis. Here we show that vti1a is absent from mature secretory vesicles in adrenal chromaffin cells, but localizes to a compartment near the trans-Golgi network, partially overlapping with syntaxin-6. Exocytosis is impaired in vti1a null cells, partly due to fewer Ca
Original languageEnglish
Pages (from-to)1681-1697
JournalEMBO Journal
Volume33
Issue number15
DOIs
Publication statusPublished - 2014

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