TY - JOUR
T1 - The social behavioral phenotype in boys and girls with an extra X chromosome (Klinefelter syndrome and Trisomy X)
T2 - A comparison with autism spectrum disorder
AU - Van Rijn, Sophie
AU - Stockmann, Lex
AU - Borghgraef, Martine
AU - Bruining, Hilgo
AU - Van Ravenswaaij-Arts, Conny
AU - Govaerts, Lutgarde
AU - Hansson, Kerstin
AU - Swaab, Hanna
PY - 2014/2
Y1 - 2014/2
N2 - The present study aimed to gain more insight in the social behavioral phenotype, and related autistic symptomatology, of children with an extra X chromosome in comparison to children with ASD. Participants included 60 children with an extra X chromosome (34 boys with Klinefelter syndrome and 26 girls with Trisomy X), 58 children with ASD and 106 controls, aged 9 to 18 years. We used the Autism Diagnostic Interview, Social Responsiveness Scale, Social Anxiety Scale and Social Skills Rating System. In the extra X group, levels of social dysfunction and autism symptoms were increased, being in between controls and ASD. In contrast to the ASD group, the extra X group showed increased social anxiety. The effects were similar for boys and girls with an extra X chromosome.
AB - The present study aimed to gain more insight in the social behavioral phenotype, and related autistic symptomatology, of children with an extra X chromosome in comparison to children with ASD. Participants included 60 children with an extra X chromosome (34 boys with Klinefelter syndrome and 26 girls with Trisomy X), 58 children with ASD and 106 controls, aged 9 to 18 years. We used the Autism Diagnostic Interview, Social Responsiveness Scale, Social Anxiety Scale and Social Skills Rating System. In the extra X group, levels of social dysfunction and autism symptoms were increased, being in between controls and ASD. In contrast to the ASD group, the extra X group showed increased social anxiety. The effects were similar for boys and girls with an extra X chromosome.
KW - Autism
KW - Klinefelter
KW - Sex chromosomal aneuploidies
KW - Social functioning
KW - Trisomy x
KW - X chromosome
UR - http://www.scopus.com/inward/record.url?scp=84899063742&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s10803-013-1860-5
DO - https://doi.org/10.1007/s10803-013-1860-5
M3 - Article
C2 - 23824705
SN - 0162-3257
VL - 44
SP - 310
EP - 320
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 2
ER -