The spatial coefficient of variation in arterial spin labeling cerebral blood flow images

Henri J.M.M. Mutsaerts, Jan Petr, Lena Václavů, Jan W. van Dalen, Andrew D. Robertson, Matthan W. Caan, Mario Masellis, Aart J. Nederveen, Edo Richard, Bradley J. MacIntosh

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Macro-vascular artifacts are a common arterial spin labeling (ASL) finding in populations with prolonged arterial transit time (ATT) and result in vascular regions with spuriously increased cerebral blood flow (CBF) and tissue regions with spuriously decreased CBF. This study investigates whether there is an association between the spatial signal distribution of a single post-label delay ASL CBF image and ATT. In 186 elderly with hypertension (46% male, 77.4 ± 2.5 years), we evaluated associations between the spatial coefficient of variation (CoV) of a CBF image and ATT. The spatial CoV and ATT metrics were subsequently evaluated with respect to their associations with age and sex – two demographics known to influence perfusion. Bland–Altman plots showed that spatial CoV predicted ATT with a maximum relative error of 7.6%. Spatial CoV was associated with age (β = 0.163, p = 0.028) and sex (β = −0.204, p = 0.004). The spatial distribution of the ASL signal on a standard CBF image can be used to infer between-participant ATT differences. In the absence of ATT mapping, the spatial CoV may be useful for the clinical interpretation of ASL in patients with cerebrovascular pathology that leads to prolonged transit of the ASL signal to tissue.

Original languageEnglish
Pages (from-to)3184-3192
Number of pages9
JournalJournal of cerebral blood flow and metabolism
Issue number9
Early online date2017
Publication statusPublished - 1 Sept 2017


  • ASL
  • Arterial spin labeling
  • cerebral blood flow
  • cerebral hemodynamics
  • perfusion weighted MRI

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